Difference between revisions of "ArsC"

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Revision as of 13:59, 16 May 2013

  • Description: arsenate reductase

Gene name arsC
Synonyms yqcM
Essential no
Product arsenate reductase
Function detoxification of arsenate
Gene expression levels in SubtiExpress: arsC
Interactions involving this protein in SubtInteract: ArsC
MW, pI 15 kDa, 4.749
Gene length, protein length 417 bp, 139 aa
Immediate neighbours spoIVCA, arsB
Sequences Protein DNA DNA_with_flanks
Genetic context
ArsC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ArsC expression.png
























Categories containing this gene/protein

resistance against toxic metals, Skin element

This gene is a member of the following regulons

ArsR regulon, SigF regulon

The gene

Basic information

  • Locus tag: BSU25780

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Protein tyrosine phosphate + H2O = protein tyrosine + phosphate (according to Swiss-Prot)
  • Protein family: ArsC family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • expressed early during sporulation in the forespore (SigF) PubMed
    • expressed in the presence of toxic metal ions (As(III), Cd(II) and Ag(I)) (ArsR) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

You Li, Yunfei Hu, Xinxin Zhang, Huimin Xu, Ewen Lescop, Bin Xia, Changwen Jin
Conformational fluctuations coupled to the thiol-disulfide transfer between thioredoxin and arsenate reductase in Bacillus subtilis.
J Biol Chem: 2007, 282(15);11078-83
[PubMed:17303556] [WorldCat.org] [DOI] (P p)

Stephanie T Wang, Barbara Setlow, Erin M Conlon, Jessica L Lyon, Daisuke Imamura, Tsutomu Sato, Peter Setlow, Richard Losick, Patrick Eichenberger
The forespore line of gene expression in Bacillus subtilis.
J Mol Biol: 2006, 358(1);16-37
[PubMed:16497325] [WorldCat.org] [DOI] (P p)

Z Guan, L Hederstedt, J Li, X D Su
Preparation and crystallization of a Bacillus subtilis arsenate reductase.
Acta Crystallogr D Biol Crystallogr: 2001, 57(Pt 11);1718-21
[PubMed:11679756] [WorldCat.org] [DOI] (P p)

T Sato, Y Kobayashi
The ars operon in the skin element of Bacillus subtilis confers resistance to arsenate and arsenite.
J Bacteriol: 1998, 180(7);1655-61
[PubMed:9537360] [WorldCat.org] [DOI] (P p)

Additional publications: PubMed