arsC

arsC
168

arsenate reductase

locus
BSU_25780
Molecular weight
15.45 kDa
pI
4.75
Protein length
Gene length
function
detoxification of arsenate
product
arsenate reductase
essential
no
ec
3.1.3.48
synonyms
arsC, yqcM

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0394 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,655,322 → 2,655,741
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The protein
Catalyzed reaction/ biological activity
[thioredoxin]-dithiol + arsenate + H+ --> [thioredoxin]-disulfide + arsenite + H2O (according to UniProt)
Protein family
low molecular weight phosphotyrosine protein phosphatase family (with [protein|2CEFD8D9692D062CC09E3DEDA1A4015C76BC4167|yfkJ] and [protein|1BAD28287257F82F907706AFD2E8FF5F3BD1B57B|ywlE], according to UniProt)
Structure
[PDB|1Z2D] (reduced form),  [PDB|1Z2E] (oxidized form),  [PDB|2IPA] (TrxA-ArsC-complex) [Pubmed|17303556],  [PDB|1JL3]
[AF|P45947]
Expression and Regulation
Operons
genes
[gene|B3D88B9C89154B77D77FB833CA16FD4F4E29FE96|arsR]-[gene|74B1AF103E6B236609CD184A1A409A9A04857181|yqcK]-[gene|B749D54249A28A471EF796903A34622A16D5B0BB|arsB]-[gene|DB3527FB78D0B7C144D1699D665788184F19AFE0|arsC]
description
[Pubmed|9537360]
regulation
expressed early during sporulation in the forespore ([protein|search|SigF]) [Pubmed|16497325]
regulatory mechanism
[protein|B3D88B9C89154B77D77FB833CA16FD4F4E29FE96|arsR]: repression, [Pubmed|9537360], in [regulon|protein:B3D88B9C89154B77D77FB833CA16FD4F4E29FE96|arsR regulon]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA]: sigma factor, [Pubmed|9537360], in [regulon|protein:360F48D576DE950DF79C1A2677B7A35A8D8CC30C|sigA regulon]
[protein|CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF]: sigma factor, [Pubmed|16497325], in [regulon|protein:CFF318EE6CACDEE763FBF96A2ABB46E944679AAA|sigF regulon]
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[gene|B3D88B9C89154B77D77FB833CA16FD4F4E29FE96|arsR]→[gene|DB3527FB78D0B7C144D1699D665788184F19AFE0|arsC]

2024-01-26 19:08:21

ghost

45

7d91428def687f36edd853c2144ba36ad881df9d

CB498A4267C57A4A9612EB861EB870A4C106D7B1

Biological materials
Mutant
BKE25780 (Δ[gene|DB3527FB78D0B7C144D1699D665788184F19AFE0|arsC]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE25780 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATATTCCACCTCTACAT,  downstream forward: _UP4_TAAATAAACTCTTTTGTTAA
BKK25780 (Δ[gene|DB3527FB78D0B7C144D1699D665788184F19AFE0|arsC]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK25780 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_CATATATTCCACCTCTACAT,  downstream forward: _UP4_TAAATAAACTCTTTTGTTAA
References
16497325,11679756,9537360,17303556,21258851,25494643

DB3527FB78D0B7C144D1699D665788184F19AFE0

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Time of last update: 2024-03-28 01:52:07

Author of last update: Melvin.boenninger