arsC
168
arsenate reductase
locus
BSU_25780
Molecular weight
15.45 kDa
pI
4.75
function
detoxification of arsenate
product
arsenate reductase
essential
no
ec
3.1.3.48
synonyms
arsC, yqcM
Outlinks
Genomic Context
Categories containing this gene/protein
List of homologs in different organisms, belongs to COG0394 (Galperin et al., 2021)
This gene is a member of the following regulons
Gene
Coordinates
2,655,322 → 2,655,741
The protein
Catalyzed reaction/ biological activity
[thioredoxin]-dithiol + arsenate + H+ --> [thioredoxin]-disulfide + arsenite + H2O (according to UniProt)
Protein family
low molecular weight phosphotyrosine protein phosphatase family (with [protein|2CEFD8D9692D062CC09E3DEDA1A4015C76BC4167|yfkJ] and [protein|1BAD28287257F82F907706AFD2E8FF5F3BD1B57B|ywlE], according to UniProt)
Structure
[PDB|1Z2D] (reduced form), [PDB|1Z2E] (oxidized form), [PDB|2IPA] (TrxA-ArsC-complex) [Pubmed|17303556], [PDB|1JL3]
[AF|P45947]
Biological materials
Mutant
BKE25780 (Δ[gene|DB3527FB78D0B7C144D1699D665788184F19AFE0|arsC]::erm trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE25780 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATATTCCACCTCTACAT, downstream forward: _UP4_TAAATAAACTCTTTTGTTAA
BKK25780 (Δ[gene|DB3527FB78D0B7C144D1699D665788184F19AFE0|arsC]::kan trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK25780 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATATATTCCACCTCTACAT, downstream forward: _UP4_TAAATAAACTCTTTTGTTAA
References
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Time of last update: 2024-04-24 09:34:07
Author of last update: Melvin.boenninger