AroH

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  • Description: chorismate mutase (isozymes 1 and 2)

Gene name aroH
Synonyms
Essential no
Product chorismate mutase (isozymes 1 and 2)
Function biosynthesis of aromatic amino acids
Gene expression levels in SubtiExpress: aroH
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp
MW, pI 14 kDa, 5.524
Gene length, protein length 381 bp, 127 aa
Immediate neighbours trpE, aroB
Sequences Protein DNA DNA_with_flanks
Genetic context
AroH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
AroH expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU22690

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Chorismate = prephenate (according to Swiss-Prot)
  • Protein family: BCKDHA family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 2CHT (complex with a transition state analog), 1DBF
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Y M Chook, H Ke, W N Lipscomb
Crystal structures of the monofunctional chorismate mutase from Bacillus subtilis and its complex with a transition state analog.
Proc Natl Acad Sci U S A: 1993, 90(18);8600-3
[PubMed:8378335] [WorldCat.org] [DOI] (P p)