AroF

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  • Description: chorismate synthase

Gene name aroF
Synonyms
Essential no
Product chorismate synthase
Function biosynthesis of aromatic amino acids
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp
MW, pI 40 kDa, 6.578
Gene length, protein length 1107 bp, 369 aa
Immediate neighbours aroB, cheR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AroF context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU22710

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate (according to Swiss-Prot)
  • Protein family: acetokinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: cytoplasm (according to Swiss-Prot)

Database entries

  • Structure: 2O11 (from Mycobacterium tuberculosis h37rv mutant, 42% identity, 58% similarity)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

S O Hoch
Mapping of the 5-methyltryptophan resistance locus in Bacillus subtilis.
J Bacteriol: 1974, 117(1);315-7
[PubMed:4202998] [WorldCat.org] [DOI] (P p)