AroC

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  • Description: 3-dehydroquinate dehydratase

Gene name aroC
Synonyms
Essential no
Product 3-dehydroquinate dehydratase
Function biosynthesis of aromatic amino acids
Gene expression levels in SubtiExpress: aroC
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp
MW, pI 27 kDa, 4.898
Gene length, protein length 765 bp, 255 aa
Immediate neighbours serA, rsiX
Sequences Protein DNA Advanced_DNA
Genetic context
AroC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
AroC expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU23080

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: 3-dehydroquinate = 3-dehydroshikimate + H2O (according to Swiss-Prot)
  • Protein family: type-I 3-dehydroquinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1GQN (from Salmonella typhi, 55% identity, 70% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

V Azevedo, A Sorokin, S D Ehrlich, P Serror
The transcriptional organization of the Bacillus subtilis 168 chromosome region between the spoVAF and serA genetic loci.
Mol Microbiol: 1993, 10(2);397-405
[PubMed:7934830] [WorldCat.org] [DOI] (P p)

R J Warburg, I Mahler, D J Tipper, H O Halvorson
Cloning the Bacillus subtilis 168 aroC gene encoding dehydroquinase.
Gene: 1984, 32(1-2);57-66
[PubMed:6442253] [WorldCat.org] [DOI] (P p)