aroB

aroB
168

3-dehydroquinate synthase

locus
BSU_22700
Molecular weight
40.66 kDa
pI
6.94
Protein length
Gene length
function
biosynthesis of aromatic amino acids
product
3-dehydroquinate synthase
essential
no
ec
4.2.3.4
synonyms
aroB

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0337 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,378,012  2,379,100
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The protein
Catalyzed reaction/ biological activity
7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate --> 3-dehydroquinate + phosphate (according to UniProt)
Protein family
sugar phosphate cyclases superfamily (single member, according to UniProt)
Structure
[PDB|3CLH] (from ''Helicobacter pylori'', 36% identity) [Pubmed|18503755]
[AF|P31102]
[wiki|Localization]
cytoplasm (according to Swiss-Prot)
Expression and Regulation
Operons
genes
[gene|1217807AE3AE3A654BA0DD4AF5ADF1CEE62632B6|cheR]-[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]-[gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]-[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]
description
[pubmed|22383849]
Open in new tab

[gene|1217807AE3AE3A654BA0DD4AF5ADF1CEE62632B6|cheR]→[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]

2024-03-16 00:20:31

Jstuelk

100

88965d20d1da4832592c311cace3ecbf90c44644

85AFABBE9DF5093CCB38A8A7CAF16B0DE8C014A7

genes
[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]-[gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]-[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]
description
[pubmed|21815947]
Open in new tab

[gene|9712D0E655289C97315314BDEE1A0DF2ED2ADCA2|aroF]→[gene|5C2F7F9F5FCBFEDF77AC41725EFDA0FAF0FC3BC1|aroH]

2024-01-26 09:26:30

Jstuelk

33

11ded187035e045106d8194f04674749e2b39e61

BB6AEFA38C0BE93441F72C5C4A7B99691660ECBA

Biological materials
Mutant
1A613 ( ''aroB''::''erm''), [Pubmed|3015878], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A613&Search=1A613 BGSC]
BKE22700 ([gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE22700 BGSC] and in [wiki|Jörg Stülke]'s lab,  [Pubmed|28189581], upstream reverse: _UP1_AGTTTGAACATGCAGTGTCT,  downstream forward: _UP4_AAATGGCGATTGGAGGAGAC
BKK22700 ([gene|58B782C1F7931F8671161455E65E3D5C72B0BB9C|aroB]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK22700 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_AGTTTGAACATGCAGTGTCT,  downstream forward: _UP4_AAATGGCGATTGGAGGAGAC
References
Reviews
12966138
Original Publications
4200844,18503755,21815947,28516784

58B782C1F7931F8671161455E65E3D5C72B0BB9C

Page visits: 3994

Time of last update: 2024-03-28 21:12:34

Author of last update: Melvin.boenninger