apt

apt
168

adenine phosphoribosyltransferase, universally conserved protein

locus
BSU_27610
Molecular weight
18.73 kDa
pI
4.7
Protein length
Gene length
function
purine salvage and interconversion
product
adenine phosphoribosyltransferase
essential
no
ec
2.4.2.7
synonyms
apt

Genomic Context

Categories containing this gene/protein

List of homologs in different organisms, belongs to COG0503 (Galperin et al., 2021)

This gene is a member of the following regulons

Gene
Coordinates
2,822,901  2,823,413
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The protein
Catalyzed reaction/ biological activity
AMP + diphosphate --> 5-phospho-α-D-ribose 1-diphosphate + adenine (according to UniProt)
Protein family
[wiki|Purine/pyrimidine phosphoribosyltransferase family] (according to UniProt)
Structure
[PDB|2DY0] (from ''Escherichia coli k12'', 56% identity, 66% similarity)
[AF|O34443]
Modification
phosphorylated on Arg-85 [Pubmed|22517742]
Additional information
[wiki|universally conserved protein]
Expression and Regulation
Operons
genes
[gene|BA755FA1CB1E0C006E9A23489A7C8997141AA498|recJ]-[gene|38DF74800FC5D54183C58B0EB82BD9A3EB93EE33|apt]
description
[Pubmed|15241682]
regulation
[protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|rel] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
regulatory mechanism
stringent response: negative regulation, in [regulon|other_regulator:stringent response|stringent response]
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[gene|BA755FA1CB1E0C006E9A23489A7C8997141AA498|recJ]→[gene|38DF74800FC5D54183C58B0EB82BD9A3EB93EE33|apt]

2024-03-10 09:02:37

Jstuelk

78

bcb4b3fd3aef4232f70aff2b81180a20d1f263e6

B255582EBC06D6885BA9D186E0A7757EA36D195A

Biological materials
Mutant
BKE27610 ([gene|38DF74800FC5D54183C58B0EB82BD9A3EB93EE33|apt]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE27610 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GTATTGTTTTAAATCCATCT,  downstream forward: _UP4_TAAGGATAACCGCATAACGA
BKK27610 ([gene|38DF74800FC5D54183C58B0EB82BD9A3EB93EE33|apt]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK27610 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_GTATTGTTTTAAATCCATCT,  downstream forward: _UP4_TAAGGATAACCGCATAACGA
References
3110131,15241682,22517742

38DF74800FC5D54183C58B0EB82BD9A3EB93EE33

Page visits: 2598

Time of last update: 2024-03-28 13:17:20

Author of last update: Melvin.boenninger