AprX

• Description: intracellular alkaline serine protease
  
  

Gene name	aprX
Synonyms
Essential	no
Product	intracellular alkaline serine protease
Function	protein degradation
Gene expression levels in SubtiExpress: aprX
MW, pI	47 kDa, 4.974
Gene length, protein length	1326 bp, 442 aa
Immediate neighbours	ymaE, ymzE/1
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

utilization of nitrogen sources other than amino acids

This gene is a member of the following regulons

LexA regulon

The gene

Basic information

• Locus tag: BSU17260

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure:

• UniProt: O31788

• KEGG entry: [3]

• E.C. number:

Expression and regulation

• Operon: aprX (according to [DBTBS])

• Expression browser: aprX PubMed

• Sigma factor: SigA PubMed

• Regulation:
  • induced by DNA damage (LexA) PubMed

• Regulatory mechanism:
  • LexA: transcription repression PubMed

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

Labs working on this gene/protein

Alessandra Albertini, University of Pavia, Italy homepage

References

Nora Au, Elke Kuester-Schoeck, Veena Mandava, Laura E Bothwell, Susan P Canny, Karen Chachu, Sierra A Colavito, Shakierah N Fuller, Eli S Groban, Laura A Hensley, Theresa C O'Brien, Amish Shah, Jessica T Tierney, Louise L Tomm, Thomas M O'Gara, Alexi I Goranov, Alan D Grossman, Charles M Lovett
Genetic composition of the Bacillus subtilis SOS system.
J Bacteriol: 2005, 187(22);7655-66
[PubMed:16267290] [WorldCat.org] [DOI] (P p)

Angela Valbuzzi, Eugenio Ferrari, Alessandra M Albertini
A novel member of the subtilisin-like protease family from Bacillus subtilis.
Microbiology (Reading): 1999, 145 ( Pt 11);3121-3127
[PubMed:10589719] [WorldCat.org] [DOI] (P p)