Alr

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  • Description: alanine racemase

Gene name alr
Synonyms dal, alrA
Essential yes PubMed
Product alanine racemase
Function peptidoglycan biosynthesis
MW, pI 43 kDa, 8.431
Gene length, protein length 1167 bp, 389 aa
Immediate neighbours ydcC, ndoAI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
Alr context.gif
This image was kindly provided by SubtiList



Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04640

Expression

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-alanine = D-alanine (according to Swiss-Prot)
  • Protein family: alanine racemase family (according to Swiss-Prot)
  • Paralogous protein(s): YncD

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1L6G (with N-[5�-phosphopyridoxyl]-D-alanine, Geobacillus stearothermophilus), 1SFT (Geobacillus stearothermophilus)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

M P Heaton, R B Johnston, T L Thompson
Controlled lysis of bacterial cells utilizing mutants with defective synthesis of D-alanine.
Can J Microbiol: 1988, 34(3);256-61
[PubMed:3138014] [WorldCat.org] [DOI] (P p)