Adk

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  • Description: adenylate kinase

Gene name adk
Synonyms
Essential yes PubMed
Product adenylate kinase
Function ADP formation
Gene expression levels in SubtiExpress: adk
Metabolic function and regulation of this protein in SubtiPathways:
adk
MW, pI 23 kDa, 4.449
Gene length, protein length 651 bp, 217 aa
Immediate neighbours secY, map
Sequences Protein DNA DNA_with_flanks
Genetic context
Adk context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Adk expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of nucleotides, essential genes

This gene is a member of the following regulons

stringent response

The gene

Basic information

  • Locus tag: BSU01370

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + AMP = 2 ADP (according to Swiss-Prot)
  • Protein family: adenylate kinase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
    • RelA dependent downregulation (Class I) during stringent response PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Thomas H Segall-Shapiro, Peter Q Nguyen, Edgardo D Dos Santos, Saurav Subedi, Justin Judd, Junghae Suh, Jonathan J Silberg
Mesophilic and hyperthermophilic adenylate kinases differ in their tolerance to random fragmentation.
J Mol Biol: 2011, 406(1);135-48
[PubMed:21145325] [WorldCat.org] [DOI] (I p)

Rafael Couñago, Corey J Wilson, Matthew I Peña, Pernilla Wittung-Stafshede, Yousif Shamoo
An adaptive mutation in adenylate kinase that increases organismal fitness is linked to stability-activity trade-offs.
Protein Eng Des Sel: 2008, 21(1);19-27
[PubMed:18093993] [WorldCat.org] [DOI] (P p)

J W Suh, S A Boylan, S H Oh, C W Price
Genetic and transcriptional organization of the Bacillus subtilis spc-alpha region.
Gene: 1996, 169(1);17-23
[PubMed:8635744] [WorldCat.org] [DOI] (P p)