Difference between revisions of "AdaB"
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| − | + | * '''Description:''' O6-methylguanine-DNA methyltransferase <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || adaptive response to alkylative DNA damage | |style="background:#ABCDEF;" align="center"|'''Function''' || adaptive response to alkylative DNA damage | ||
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 6.152 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 19 kDa, 6.152 | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:adaB_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:adaB_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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__TOC__ | __TOC__ | ||
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* '''Operon:''' ''[[adaA]]-[[adaB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed] | * '''Operon:''' ''[[adaA]]-[[adaB]]'' [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed] | ||
| − | * | + | * '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed] |
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* '''Regulation:''' positive control by [[AdaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed] | * '''Regulation:''' positive control by [[AdaA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/2120677 PubMed] | ||
Revision as of 10:16, 7 August 2012
- Description: O6-methylguanine-DNA methyltransferase
| Gene name | adaB |
| Synonyms | |
| Essential | no |
| Product | O6-methylguanine-DNA methyltransferase |
| Function | adaptive response to alkylative DNA damage |
| MW, pI | 19 kDa, 6.152 |
| Gene length, protein length | 537 bp, 179 aa |
| Immediate neighbours | adaA, ndhF |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU01820
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: DNA (containing 6-O-methylguanine) + protein L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine (according to Swiss-Prot)
- Protein family: MGMT family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P19220
- KEGG entry: [3]
- E.C. number: 2.1.1.63
Additional information
Expression and regulation
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
F Morohoshi, K Hayashi, N Munakata
Bacillus subtilis ada operon encodes two DNA alkyltransferases.
Nucleic Acids Res: 1990, 18(18);5473-80
[PubMed:2120677]
[WorldCat.org]
[DOI]
(P p)
