acdA

168

acyl-CoA dehydrogenase

locus: BSU_37170

Molecular weight: 41.29 kDa

pI: 4.95

Protein length: 379 aa

Gene length: 1140 bp

function: fatty acid degradation

product: acyl-CoA dehydrogenase

essential: no

synonyms: acdA

List of homologs in different organisms, belongs to COG1960 (Galperin et al., 2021)

Gene

Coordinates: 3,813,246  3,814,385

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The protein

Catalyzed reaction/ biological activity

• A + 2,3-saturated acyl-CoA --> 2,3-dehydroacyl-CoA + AH₂ (according to UniProt)

Protein family

• [wiki|Acyl-CoA dehydrogenase family] (according to UniProt)

[wiki|Cofactors]

• FAD (according to UniProt)

Structure

• [PDB|2Z1Q] (from ''Thermus thermophilus hb8'', 40% identity, 55% similarity)
• [AF|P45867]

Paralogous protein(s)

• [protein|B5325CBF1408E2CA227EB462092E209F4C87E797|fadE], [protein|BA28DFBAF88A4994B0541D1FF2187312FDE1FA15|yngJ], [protein|F25CDDEBAFC72036664323619F5197D45E86BE9A|mmgC]

Biological materials

Mutant

• BKE37170 ([gene|7D89BBB52403BF99416250688EFA90C2BE8EB591|acdA]::erm  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKE37170 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATTCATTGCTTCTCCCCCAT,  downstream forward: _UP4_TAACGGAAAACATCTCTCAG
• BKK37170 ([gene|7D89BBB52403BF99416250688EFA90C2BE8EB591|acdA]::kan  trpC2) available at [http://bgsc.org/getdetail.php?bgscid=BKK37170 BGSC],  [Pubmed|28189581], upstream reverse: _UP1_ATTCATTGCTTCTCCCCCAT,  downstream forward: _UP4_TAACGGAAAACATCTCTCAG

References

• 17189250,17919287