AccC

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  • Description: acetyl-CoA carboxylase (biotin carboxylase UE)

Gene name accC
Synonyms yqhX
Essential yes PubMed
Product acetyl-CoA carboxylase (biotin carboxylase UE))
Function production of malonyl-CoA, the substrate for fatty acid biosynthesis
MW, pI 49 kDa, 4.72
Gene length, protein length 1350 bp, 450 aa
Immediate neighbours yqhY, accB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
AccC context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU24340

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s): YotE

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

P Marini, S J Li, D Gardiol, J E Cronan, D de Mendoza
The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis.
J Bacteriol: 1995, 177(23);7003-6
[PubMed:7592499] [WorldCat.org] [DOI] (P p)

  1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed