Difference between revisions of "ABC transporters"

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(Created page with " {{CategoryTree |Parents= * 1. Cellular processes ** 1.2. Transporters |Neighbours= * 1.2.1. ABC transporters * 1.2.2. Phosphotransferase systems * 1.2.3. [[Trans...")
 
(→‎Relevant publications)
 
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{{CategoryTree
 
{{CategoryTree
 
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* 1.2.1. [[ABC transporters]]
 
* 1.2.1. [[ABC transporters]]
 
* 1.2.2. [[Phosphotransferase systems]]
 
* 1.2.2. [[Phosphotransferase systems]]
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* 1.2.3. [[Transporters/ other]]
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* 1.2.3. [[ECF transporter]]
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* 1.2.4. [[Transporters/ other]]
 
|Related=
 
|Related=
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none
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[[transport proteins]]
 
|}}
 
|}}
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__TOC__
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<br>
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=Importers=
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==Uptake of carbon sources==
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* [[YurJ]]-([[FrlM]]-[[FrlN]])-[[FrlO]]: uptake of aminosugars
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* [[AraN]], [[AraP]], [[AraQ]]: uptake of α-1,5-arabinooligosaccharides
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* [[CycB]], [[GanP]], [[GanQ]]: uptake of galactotriose
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* [[MdxE]], [[MdxF]], [[MdxG]]: uptake of maltodextrin
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* [[AmyC]], [[AmyD]], [[MsmE]]: uptake of melibiose (probably)
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* [[RbsA]], [[RbsB]], [[RbsC]], [[RbsD]]: uptake of ribose
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* [[RhiL]]-[[RhiF]]-[[RhiG]]: uptake of rhamnose oligosaccharides
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* [[YtcP]]-[[YtcQ]]-[[YteP]]: uptake of polygalacturonan and rhamnogalacturonan
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===ATPase subunit of multiple sugar transport systems===
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* [[MsmX]]
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==Uptake of amino acids==
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* [[ArtP]], [[ArtQ]], [[ArtR]]: uptake of arginine
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* [[TcyJ]], [[TcyK]], [[TcyL]], [[TcyM]], [[TcyN]]: uptake of cystine
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* [[TcyA]], [[TcyB]], [[TcyC]]: uptake of cystine
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* [[YxeM]]-[[YxeN]]-[[YxeO]]: uptake of S-(2-succino)cysteine (putative)
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* [[GlnH]], [[GlnM]], [[GlnP]], [[GlnQ]]: uptake of glutamine
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* [[MetN]], [[MetP]], [[MetQ]]: uptake of methionine
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==Uptake of nucleosides==
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* [[NupO]]-[[NupP]]-[[NupQ]]: uptake of guanosine
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==Uptake of peptides==
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* [[AppA]], [[AppB]], [[AppC]], [[AppD]], [[AppF]]: uptake of oligopeptides
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* [[DppB]], [[DppC]], [[DppD]], [[DppE]], [[YkfD]]: uptake of dipeptides
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* [[OppA]], [[OppB]], [[OppC]], [[OppD]], [[OppF]]: uptake of oligopeptides
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==Uptake of compatible solutes for osmoprotection==
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* [[OpuAA]]-[[OpuAB]]-[[OpuAC]]: [[ABC transporter]] for glycine betaine
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* [[OpuBA]]-[[OpuBB]]-[[OpuBC]]-[[OpuBD]]: [[ABC transporter]] for choline
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* [[OpuCA]]-[[OpuCB]]-[[OpuCC]]-[[OpuCD]]: [[ABC transporter]] for glycine betaine/ carnitine/ choline
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==Uptake of cofactors==
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* [[YvrA]]-[[YvrB]]-[[YvrC]]: uptake of cobalamin
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==[[Iron metabolism|Uptake of iron/ siderophores]]==
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* [[YusV]]-[[FeuB]]-[[FeuC]]-[[FeuA]]: uptake of the siderophores enterobactin and bacillibactin
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* [[FhuC]]-[[FhuB]]-[[FhuG]]-[[FhuD]]-[[YxeB]]: uptake of ferrichrome und ferrioxamine
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* [[YclN]]-[[YclO]]-[[YclP]]-[[YclQ]]: uptake of petrobactin (a siderophore produced by ''B. anthracis'' and ''B. cereus'')
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* [[YusV]]-[[YfiZ]]-[[YfhA]]-[[YfiY]]: uptake of the siderophores schizokinen and arthrobactin
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* [[YfmF]]-[[YfmD]]-[[YfmE]]-[[YfmC]]-[[YhfQ]]: uptake of iron/citrate
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==Uptake of ions==
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* [[MntB]]-[[MntA]]-[[MntC]]-[[MntD]]: uptake of manganese
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* [[PstBA]]-[[PstBB]]-[[PstS]]-[[PstC]]-[[PstA]]: uptake of phosphate
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* [[SsuA]]-[[SsuB]]-[[SsuC]]: uptake of aliphatic sulfonate
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* [[ZnuA]]-[[ZnuB]]-[[ZnuC]]: uptake of zinc
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* [[YvgM]]-[[YvgL]]: uptake of molybdenum (probably)
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==ABC transporters of unknown function==
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* [[LplA]]-[[LplB]]-[[LplC]]
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* [[YckA]]-[[YckB]]
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* [[YhcJ]]
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* [[YhjP]]
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* [[YjkB]]-[[YjkA]]
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* [[YlmA]]
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* [[YtlC]]-[[YtlD]]-[[YtlA]]
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* ([[YtrB]]-[[YtrE]])-([[YtrC]]-[[YtrD]])-[[YtrF]]
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=Exporters=
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==Efflux of antibiotics==
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* [[VmlR]]: efflux of virginiamycin M and lincomycin
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* [[BmrA]]: efflux of multiple antibiotics
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* [[BmrC]]-[[BmrD]]: efflux of multiple antibiotics
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* [[YfiL]]-[[YfiM]]-[[YfiN]]: probably efflux of linearmcin
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==Export of antibiotic substances==
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* [[AlbC]]-[[AlbD]]
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* [[SunT]]
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==Export of peptides==
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* [[SkfE]]-[[SkfF]]: export of the [[skfA|spore killing factor]]
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* [[YknY]]-[[YknZ]]
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* [[BceA]]-[[BceB]]: export of bacitracin, plectasin, mersacidin and actagardine
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* [[YxdL]]-[[YxdM]]
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* [[PsdA]]-[[PsdB]]: export of lipid II-binding lantibiotics, such as nisin and gallidermin
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* [[YxlF]]-[[YxlG]]
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* [[YydI]]-[[YydJ]]: export of the modified [[YydF]] epipeptide, control of [[LiaR]]-[[LiaS]] activity
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==Export of cell wall components==
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* [[TagG]]-[[TagH]]: export of teichoic acid
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==Export of ions==
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* [[NatA]]-[[NatB]]: export of Na(+)
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==Exporters of unknown function==
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* [[YcbN]]
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* [[YclH]]-[[YclI]]
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* [[YdbJ]]-[[YdbK]]
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* [[YdiF]]
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* [[YfiB]]-[[YfiC]]
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* [[YfmM]]
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* [[YfmR]]
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* [[YgaD]]
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* [[YhaQ]]-[[YhaP]]
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* [[YhcG]]-[[YhcE]]
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* [[YhcH]]-[[YhcI]]
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* [[YknU]]-[[YknV]]
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* [[YkpA]]
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* [[YthP]]-[[YthQ]]
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* [[YvfR]]-[[YvfS]]
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* [[YvrO]]-[[YvrN]]
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* [[YwjA]]
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* [[YybJ]]-([[YybK]]-[[YybL]])
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=Regulatory ABC transporters=
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* [[CydC]]-[[CydD]]: required for expression of cytochrome bd
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* [[EcsA]]-[[EcsB]]: regulation of the secretion apparatus and of intra-membrane proteolysis
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* [[FtsE]]-[[FtsX]]: activation of [[Spo0A]] and initiation of sporulation
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* [[BmrC]]-[[BmrD]]: involved in the signalling pathway to activate [[KinA]] at the onset of sporulation
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* [[SufC]]: required for the [[Iron metabolism|synthesis of Fe-S clusters]]
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=Relevant publications=
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<pubmed> 10092453 1282354 18535149 20497229 21665979 23106164 27273632 ,32569521</pubmed>
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=Back to [[categories]]=

Latest revision as of 09:34, 25 June 2020

Parent categories
Neighbouring categories
Related categories

transport proteins


Importers

Uptake of carbon sources

ATPase subunit of multiple sugar transport systems

Uptake of amino acids

Uptake of nucleosides

Uptake of peptides

Uptake of compatible solutes for osmoprotection

Uptake of cofactors

Uptake of iron/ siderophores

Uptake of ions

ABC transporters of unknown function

Exporters

Efflux of antibiotics

  • VmlR: efflux of virginiamycin M and lincomycin
  • BmrA: efflux of multiple antibiotics
  • BmrC-BmrD: efflux of multiple antibiotics
  • YfiL-YfiM-YfiN: probably efflux of linearmcin

Export of antibiotic substances

Export of peptides

Export of cell wall components

Export of ions

Exporters of unknown function

Regulatory ABC transporters

Relevant publications

Christoph Thomas, Robert Tampé
Structural and Mechanistic Principles of ABC Transporters.
Annu Rev Biochem: 2020, 89;605-636
[PubMed:32569521] [WorldCat.org] [DOI] (I p)

Kaspar P Locher
Mechanistic diversity in ATP-binding cassette (ABC) transporters.
Nat Struct Mol Biol: 2016, 23(6);487-93
[PubMed:27273632] [WorldCat.org] [DOI] (I p)

Susanne Gebhard
ABC transporters of antimicrobial peptides in Firmicutes bacteria - phylogeny, function and regulation.
Mol Microbiol: 2012, 86(6);1295-317
[PubMed:23106164] [WorldCat.org] [DOI] (I p)

Sebastian Dintner, Anna Staron, Evi Berchtold, Tobias Petri, Thorsten Mascher, Susanne Gebhard
Coevolution of ABC transporters and two-component regulatory systems as resistance modules against antimicrobial peptides in Firmicutes Bacteria.
J Bacteriol: 2011, 193(15);3851-62
[PubMed:21665979] [WorldCat.org] [DOI] (I p)

Thomas Eitinger, Dmitry A Rodionov, Mathias Grote, Erwin Schneider
Canonical and ECF-type ATP-binding cassette importers in prokaryotes: diversity in modular organization and cellular functions.
FEMS Microbiol Rev: 2011, 35(1);3-67
[PubMed:20497229] [WorldCat.org] [DOI] (I p)

Amy L Davidson, Elie Dassa, Cedric Orelle, Jue Chen
Structure, function, and evolution of bacterial ATP-binding cassette systems.
Microbiol Mol Biol Rev: 2008, 72(2);317-64, table of contents
[PubMed:18535149] [WorldCat.org] [DOI] (I p)

Y Quentin, G Fichant, F Denizot
Inventory, assembly and analysis of Bacillus subtilis ABC transport systems.
J Mol Biol: 1999, 287(3);467-84
[PubMed:10092453] [WorldCat.org] [DOI] (P p)

C F Higgins
ABC transporters: from microorganisms to man.
Annu Rev Cell Biol: 1992, 8;67-113
[PubMed:1282354] [WorldCat.org] [DOI] (P p)


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