YjbH

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  • Description: stimulation of Spx degradation

Gene name yjbH
Synonyms
Essential no
Product unknown
Function stimulation of Spx degradation
MW, pI 31 kDa, 5.206
Gene length, protein length 825 bp, 275 aa
Immediate neighbours pepF, yjbI
Gene sequence (+200bp) Protein sequence
Genetic context
YjbH context.gif



The gene

Basic information

  • Coordinates:

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: adaptor protein for ClpXP-catalyzed Spx degradation PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):contains Zn atoms (coordinated by the N-terminal His-rich region) PubMed
  • Effectors of protein activity: Zn atom is released upon treatment with strong oxidants PubMed
  • Localization:

Database entries

  • Structure:
  • Swiss prot entry:
  • KEGG entry:
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Peter Zuber, Oregon Health and Science University, USA Homepage

Claes von Wachenfeldt, Lund University, Sweden Homepage

Your additional remarks

References

  1. Garg et al. 2009. The YjbH protein of Bacillus subtilis enhances ClpXP-catalyzed proteolysis of Spx. J. Bacteriol. 191: 1268-1277. PubMed
  2. Larsson, J. T., A. Rogstam, and C. von Wachenfeldt. 2007. YjbH is a novel negative effector of the disulphide stress regulator, Spx, in Bacillus subtilis. Mol. Microbiol. 66:669-684. PubMed