HisD

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  • Description: histidinol dehydrogenase

Gene name hisD
Synonyms
Essential no
Product histidinol dehydrogenase
Function biosynthesis of histidine
Gene expression levels in SubtiExpress: hisD
Metabolic function and regulation of this protein in SubtiPathways:
hisD
MW, pI 46 kDa, 4.777
Gene length, protein length 1281 bp, 427 aa
Immediate neighbours hisB, hisG
Sequences Protein DNA DNA_with_flanks
Genetic context
HisD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
HisD expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU34910

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-histidinol + 2 NAD+ = L-histidine + 2 NADH (according to Swiss-Prot)
  • Protein family: histidinol dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1KAH (with product and NAD from Escherichia coli, 39% identity, 58% similarity) PubMed
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation: repressed by casamino acids PubMed
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 487 PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References