LipA
Revision as of 09:56, 17 April 2014 by 134.76.70.252 (talk)
- Description: trigger enzyme: lipoic acid synthase and regulator of comE operon expression
Gene name | lipA |
Synonyms | yutB |
Essential | Yes PubMed |
Product | trigger enzyme: lipoic acid synthase |
Function | lipid metabolism, required for the synthesis of branched-chain amino acids |
Gene expression levels in SubtiExpress: lipA | |
Metabolic function and regulation of this protein in SubtiPathways: LipA | |
MW, pI | 33 kDa, 8.251 |
Gene length, protein length | 894 bp, 298 aa |
Immediate neighbours | yutC, lytH |
Sequences | Protein DNA DNA_with_flanks |
Genetic context This image was kindly provided by SubtiList
| |
Expression at a glance PubMed |
Contents
Categories containing this gene/protein
biosynthesis of cofactors, trigger enzyme
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU32330
Phenotypes of a mutant
reduced transformation efficiency PubMed, strong inhibition of growth on minimal media PubMed
Database entries
- BsubCyc: BSU32330
- DBTBS entry: no entry
- SubtiList entry: [1]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Protein N(6)-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N(6)-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosine (according to Swiss-Prot) Triacylglycerol + H2O = diacylglycerol + a carboxylate (according to Swiss-Prot) required for comEA transcription PubMed
- Protein family: Lipoyl synthase family (according to Swiss-Prot) AB hydrolase superfamily (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
- extracellular (signal peptide) PubMed
Database entries
- BsubCyc: BSU32330
- Structure:
- E.C. number: 2.8.1.8 3.1.1.3]
Additional information
Expression and regulation
- Operon:
- Sigma factor:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References