LipM

• Description: octanoyltransferase
  
  

Gene name	lipM
Synonyms	yqhM
Essential	no
Product	octanoyltransferase
Function	biosynthesis of lipoic acid
Gene expression levels in SubtiExpress: lipM
Metabolic function and regulation of this protein in SubtiPathways: LipM
MW, pI	32 kDa, 5.934
Gene length, protein length	834 bp, 278 aa
Immediate neighbours	mntR, yqhL
Sequences	Protein DNA DNA_with_flanks
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU24530

Database entries

• BsubCyc: BSU24530

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:
  • transfers the octanoyl moiety from octanoyl-acyl carrier protein to the lipoyl domains of the 2-oxoacid dehydrogenases via a thioester-linked octanoyl-LipM intermediate PubMed

• Protein family:

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:
  • cytoplasm (according to Swiss-Prot)

Database entries

• BsubCyc: BSU24530

• Structure:

• UniProt: P54511

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Expression browser: lipM PubMed

• Sigma factor:

• Regulation: induced by valine PubMed

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Quin H Christensen, John E Cronan
Lipoic acid synthesis: a new family of octanoyltransferases generally annotated as lipoate protein ligases.
Biochemistry: 2010, 49(46);10024-36
[PubMed:20882995] [WorldCat.org] [DOI] (I p)