SpoVC

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  • Description: general stress protein, peptidyl-tRNA hydrolase

Gene name spoVC
Synonyms pth
Essential yes PubMed
Product peptidyl-tRNA hydrolase
Function spore coat formation
Gene expression levels in SubtiExpress: spoVC
MW, pI 20 kDa, 5.58
Gene length, protein length 564 bp, 188 aa
Immediate neighbours ctc, fin
Sequences Protein DNA DNA_with_flanks
Genetic context
SpoVC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SpoVC expression.png
























Categories containing this gene/protein

translation, general stress proteins (controlled by SigB), essential genes

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

  • Locus tag: BSU00530

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA (according to Swiss-Prot)
  • Protein family: PTH family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jeanne Menez, Richard H Buckingham, Miklos de Zamaroczy, Celine Karmazyn Campelli
Peptidyl-tRNA hydrolase in Bacillus subtilis, encoded by spoVC, is essential to vegetative growth, whereas the homologous enzyme in Saccharomyces cerevisiae is dispensable.
Mol Microbiol: 2002, 45(1);123-9
[PubMed:12100553] [WorldCat.org] [DOI] (P p)

A Petersohn, M Brigulla, S Haas, J D Hoheisel, U Völker, M Hecker
Global analysis of the general stress response of Bacillus subtilis.
J Bacteriol: 2001, 183(19);5617-31
[PubMed:11544224] [WorldCat.org] [DOI] (P p)