MnaA

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  • Description: UDP-N-acetylglucosamine 2-epimerase

Gene name mnaA
Synonyms yvyH
Essential yes PubMed
Product UDP-N-acetylglucosamine 2-epimerase
Function biosynthesis of teichoic acid
Gene expression levels in SubtiExpress: mnaA
MW, pI 42 kDa, 5.469
Gene length, protein length 1140 bp, 380 aa
Immediate neighbours tagU, gtaB
Sequences Protein DNA DNA_with_flanks
Genetic context
YvyH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MnaA expression.png
























Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU35660

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine (according to Swiss-Prot)
  • Protein family: UDP-N-acetylglucosamine 2-epimerase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Sheng-Chia Chen, Chi-Hung Huang, Chia Shin Yang, Jai-Shin Liu, Shu-Min Kuan, Yeh Chen
Crystal structures of the archaeal UDP-GlcNAc 2-epimerase from Methanocaldococcus jannaschii reveal a conformational change induced by UDP-GlcNAc.
Proteins: 2014, 82(7);1519-26
[PubMed:24470206] [WorldCat.org] [DOI] (I p)

J Badger, J M Sauder, J M Adams, S Antonysamy, K Bain, M G Bergseid, S G Buchanan, M D Buchanan, Y Batiyenko, J A Christopher, S Emtage, A Eroshkina, I Feil, E B Furlong, K S Gajiwala, X Gao, D He, J Hendle, A Huber, K Hoda, P Kearins, C Kissinger, B Laubert, H A Lewis, J Lin, K Loomis, D Lorimer, G Louie, M Maletic, C D Marsh, I Miller, J Molinari, H J Muller-Dieckmann, J M Newman, B W Noland, B Pagarigan, F Park, T S Peat, K W Post, S Radojicic, A Ramos, R Romero, M E Rutter, W E Sanderson, K D Schwinn, J Tresser, J Winhoven, T A Wright, L Wu, J Xu, T J R Harris
Structural analysis of a set of proteins resulting from a bacterial genomics project.
Proteins: 2005, 60(4);787-96
[PubMed:16021622] [WorldCat.org] [DOI] (I p)

Blazenka Soldo, Vladimir Lazarevic, Harold M Pooley, Dimitri Karamata
Characterization of a Bacillus subtilis thermosensitive teichoic acid-deficient mutant: gene mnaA (yvyH) encodes the UDP-N-acetylglucosamine 2-epimerase.
J Bacteriol: 2002, 184(15);4316-20
[PubMed:12107153] [WorldCat.org] [DOI] (P p)