YlmB

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  • Description: N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase



Gene name ylmB
Synonyms
Essential no
Product N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine deformylase
Function thiamine salvage
Gene expression levels in SubtiExpress: ylmB
Metabolic function and regulation of this protein in SubtiPathways:
ylmB
MW, pI 47 kDa, 4.981
Gene length, protein length 1278 bp, 426 aa
Immediate neighbours ylmA, ylmC
Sequences Protein DNA DNA_with_flanks
Genetic context
YlmB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
YlmB expression.png















Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

Thi-box

The gene

Basic information

  • Locus tag: BSU15350

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: N-formyl-4-amino-5-aminomethyl-2-methylpyrimidine + H2O = formate + 4-amino-5-aminomethyl-2-methylpyrimidine (according to Swiss-Prot)
  • Protein family:
  • Paralogous protein(s): YodQ

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):Binds 2 zinc or cobalt ions per subunit (according to Swiss-Prot)
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Amy Haas Jenkins, Ghislain Schyns, Sébastien Potot, Guangxing Sun, Tadhg P Begley
A new thiamin salvage pathway.
Nat Chem Biol: 2007, 3(8);492-7
[PubMed:17618314] [WorldCat.org] [DOI] (P p)

Dmitry A Rodionov, Alexey G Vitreschak, Andrey A Mironov, Mikhail S Gelfand
Comparative genomics of thiamin biosynthesis in procaryotes. New genes and regulatory mechanisms.
J Biol Chem: 2002, 277(50);48949-59
[PubMed:12376536] [WorldCat.org] [DOI] (P p)