Alr

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Gene name alr
Synonyms dal, alrA
Essential yes PubMed
Product alanine racemase
Function peptidoglycan biosynthesis
Gene expression levels in SubtiExpress: alr
MW, pI 43 kDa, 8.431
Gene length, protein length 1167 bp, 389 aa
Immediate neighbours ydcC, ndoAI
Sequences Protein DNA DNA_with_flanks
Genetic context
Alr context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Alr expression.png
























Categories containing this gene/protein

cell wall synthesis, biosynthesis of cell wall components, essential genes

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04640

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-alanine = D-alanine (according to Swiss-Prot)
  • Protein family: alanine racemase family (according to Swiss-Prot)
  • Paralogous protein(s): YncD

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1L6G (with N-[5�-phosphopyridoxyl]-D-alanine, Geobacillus stearothermophilus), 1SFT (Geobacillus stearothermophilus)
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

M P Heaton, R B Johnston, T L Thompson
Controlled lysis of bacterial cells utilizing mutants with defective synthesis of D-alanine.
Can J Microbiol: 1988, 34(3);256-61
[PubMed:3138014] [WorldCat.org] [DOI] (P p)