Cdd

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  • Description: cytidine deaminase

Gene name cdd
Synonyms
Essential no
Product cytidine deaminase
Function pyrimidine interconversion
Gene expression levels in SubtiExpress: cdd
Metabolic function and regulation of this protein in SubtiPathways:
Nucleoside catabolism, Nucleotides (regulation)
MW, pI 14 kDa, 4.7
Gene length, protein length 408 bp, 136 aa
Immediate neighbours era, dgkA
Sequences Protein DNA Advanced_DNA
Genetic context
Cdd context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Cdd expression.png




























Categories containing this gene/protein

nucleotide metabolism/ other

This gene is a member of the following regulons

SigB regulon

The gene

Basic information

  • Locus tag: BSU25300

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Cytidine + H2O = uridine + NH3 (according to Swiss-Prot)
  • Protein family: cytidine and deoxycytidylate deaminase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 1JTK (complex with inhibitor), 1UWZ (with Arg56Ala substitution)
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

N Mejlhede, J F Atkins, J Neuhard
Ribosomal -1 frameshifting during decoding of Bacillus subtilis cdd occurs at the sequence CGA AAG.
J Bacteriol: 1999, 181(9);2930-7
[PubMed:10217788] [WorldCat.org] [DOI] (P p)

B H Song, J Neuhard
Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase.
Mol Gen Genet: 1989, 216(2-3);462-8
[PubMed:2526291] [WorldCat.org] [DOI] (P p)

P Z Wang, R H Doi
Overlapping promoters transcribed by bacillus subtilis sigma 55 and sigma 37 RNA polymerase holoenzymes during growth and stationary phases.
J Biol Chem: 1984, 259(13);8619-25
[PubMed:6330116] [WorldCat.org] (P p)