GsaB

• Description: glutamate-1-semialdehyde aminotransferase
  
  

Gene name	gsaB
Synonyms
Essential	no
Product	glutamate-1-semialdehyde aminotransferase
Function	biosynthesis of heme
Gene expression levels in SubtiExpress: gsaB
MW, pI	46 kDa, 5.644
Gene length, protein length	1287 bp, 429 aa
Immediate neighbours	ygaE, ygaF
Sequences	Protein DNA Advanced_DNA
Genetic context This image was kindly provided by SubtiList
Expression at a glance   PubMed

Categories containing this gene/protein

biosynthesis of cofactors

The gene

Basic information

• Locus tag: BSU08710

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate (according to Swiss-Prot)

• Protein family: HemL subfamily (according to Swiss-Prot)

• Paralogous protein(s): HemL

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 3BS8 (HemL) PubMed

• UniProt: P71084

• KEGG entry: [2]

• E.C. number: 5.4.3.8

Expression and regulation

• Operon:

• Expression browser: gsaB PubMed

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Honghua Ge, Xinhuai Lv, Jun Fan, Yongxiang Gao, Maikun Teng, Liwen Niu
Crystal structure of glutamate-1-semialdehyde aminotransferase from Bacillus subtilis with bound pyridoxamine-5'-phosphate.
Biochem Biophys Res Commun: 2010, 402(2);356-60
[PubMed:20946885] [WorldCat.org] [DOI] (I p)