GerBC

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  • Description: lipoprotein, nutrient receptor, germination response to the combination of glucose, fructose, and KCl

Gene name gerBC
Synonyms
Essential no
Product nutrient receptor
Function germination
Gene expression levels in SubtiExpress: gerBC
Interactions involving this protein in SubtInteract: GerBC
MW, pI 42 kDa, 9.06
Gene length, protein length 1122 bp, 374 aa
Immediate neighbours gerBB, ywtG
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
GerBC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GerBC expression.png















Categories containing this gene/protein

germination, membrane proteins

This gene is a member of the following regulons

SigG regulon

The gene

Basic information

  • Locus tag: BSU35820

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: gerABKC lipoprotein family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
    • has an N-terminal signal sequence, lipidated on a Cys residue adjacent to the signal peptide PubMed
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
    • expressed late during sporulation in the forespore (SigG) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Jing-qiao Zhang, Keren K Griffiths, Ann Cowan, Peter Setlow, Ji Yu
Expression level of Bacillus subtilis germinant receptors determines the average rate but not the heterogeneity of spore germination.
J Bacteriol: 2013, 195(8);1735-40
[PubMed:23396907] [WorldCat.org] [DOI] (I p)

George Korza, Peter Setlow
Topology and accessibility of germination proteins in the Bacillus subtilis spore inner membrane.
J Bacteriol: 2013, 195(7);1484-91
[PubMed:23335419] [WorldCat.org] [DOI] (I p)

Kerry-Ann V Stewart, Xuan Yi, Sonali Ghosh, Peter Setlow
Germination protein levels and rates of germination of spores of Bacillus subtilis with overexpressed or deleted genes encoding germination proteins.
J Bacteriol: 2012, 194(12);3156-64
[PubMed:22493018] [WorldCat.org] [DOI] (I p)

Keren K Griffiths, Jingqiao Zhang, Ann E Cowan, Ji Yu, Peter Setlow
Germination proteins in the inner membrane of dormant Bacillus subtilis spores colocalize in a discrete cluster.
Mol Microbiol: 2011, 81(4);1061-77
[PubMed:21696470] [WorldCat.org] [DOI] (I p)

Yunfeng Li, Parvathimadhavi Catta, Kerry-Ann V Stewart, Matthew Dufner, Peter Setlow, Bing Hao
Structure-based functional studies of the effects of amino acid substitutions in GerBC, the C subunit of the Bacillus subtilis GerB spore germinant receptor.
J Bacteriol: 2011, 193(16);4143-52
[PubMed:21685283] [WorldCat.org] [DOI] (I p)

Yunfeng Li, Barbara Setlow, Peter Setlow, Bing Hao
Crystal structure of the GerBC component of a Bacillus subtilis spore germinant receptor.
J Mol Biol: 2010, 402(1);8-16
[PubMed:20654628] [WorldCat.org] [DOI] (I p)

Swaroopa Atluri, Katerina Ragkousi, Donna E Cortezzo, Peter Setlow
Cooperativity between different nutrient receptors in germination of spores of Bacillus subtilis and reduction of this cooperativity by alterations in the GerB receptor.
J Bacteriol: 2006, 188(1);28-36
[PubMed:16352818] [WorldCat.org] [DOI] (P p)

Takao Igarashi, Peter Setlow
Interaction between individual protein components of the GerA and GerB nutrient receptors that trigger germination of Bacillus subtilis spores.
J Bacteriol: 2005, 187(7);2513-8
[PubMed:15774895] [WorldCat.org] [DOI] (P p)

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

Rosa-Martha Cabrera-Martinez, Federico Tovar-Rojo, Venkata Ramana Vepachedu, Peter Setlow
Effects of overexpression of nutrient receptors on germination of spores of Bacillus subtilis.
J Bacteriol: 2003, 185(8);2457-64
[PubMed:12670969] [WorldCat.org] [DOI] (P p)

B M Corfe, A Moir, D Popham, P Setlow
Analysis of the expression and regulation of the gerB spore germination operon of Bacillus subtilis 168.
Microbiology (Reading): 1994, 140 ( Pt 11);3079-83
[PubMed:7812448] [WorldCat.org] [DOI] (P p)

B M Corfe, R L Sammons, D A Smith, C Mauël
The gerB region of the Bacillus subtilis 168 chromosome encodes a homologue of the gerA spore germination operon.
Microbiology (Reading): 1994, 140 ( Pt 3);471-8
[PubMed:8012571] [WorldCat.org] [DOI] (P p)