MmgB

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  • Description: 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)

Gene name mmgB
Synonyms yqiM
Essential no
Product 3-hydroxyacyl-CoA dehydrogenase (acetoacetyl-CoA)
Function mother cell metabolism
Gene expression levels in SubtiExpress: mmgB
Metabolic function and regulation of this protein in SubtiPathways:
Central C-metabolism
MW, pI 26 kDa, 6.602
Gene length, protein length 732 bp, 244 aa
Immediate neighbours mmgC, mmgA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MmgB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MmgB expression.png




























Categories containing this gene/protein

sporulation proteins, poorly characterized/ putative enzymes

This gene is a member of the following regulons

CcpA regulon, SigE regulon

The gene

Basic information

  • Locus tag: BSU24160

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH (according to Swiss-Prot)
  • Protein family: 3-hydroxyacyl-CoA dehydrogenase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
    • expressed early during sporulation in the mother cell (SigE) PubMed
    • repressed by glucose (CcpA) PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Leif Steil, Mónica Serrano, Adriano O Henriques, Uwe Völker
Genome-wide analysis of temporally regulated and compartment-specific gene expression in sporulating cells of Bacillus subtilis.
Microbiology (Reading): 2005, 151(Pt 2);399-420
[PubMed:15699190] [WorldCat.org] [DOI] (P p)

E M Bryan, B W Beall, C P Moran
A sigma E dependent operon subject to catabolite repression during sporulation in Bacillus subtilis.
J Bacteriol: 1996, 178(16);4778-86
[PubMed:8759838] [WorldCat.org] [DOI] (P p)