DapA

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  • Description: dihydrodipicolinate synthase

Gene name dapA
Synonyms
Essential yes PubMed
Product dihydrodipicolinate synthase
Function biosynthesis of lysine and peptidoglycan
Metabolic function and regulation of this protein in SubtiPathways:
Lys, Thr
MW, pI 30 kDa, 4.928
Gene length, protein length 870 bp, 290 aa
Immediate neighbours dapG, rnjB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
DapA context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, sporulation proteins, essential genes

This gene is a member of the following regulons

SigK regulon

The gene

Basic information

  • Locus tag: BSU16770

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O (according to Swiss-Prot)
  • Protein family: DHDPS family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure: 3CPR (from Corynebacterium glutamicum, 39% identity, 58% similarity) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References