RecG

• Description: ATP-dependent DNA helicase, branch migration translocase, required for DNA repair and chromosomal segregation
  
  

Gene name	recG
Synonyms	ylpB
Essential	no
Product	ATP-dependent DNA helicase, branch migration translocase
Function	DNA repair and chromosomal segregation
Metabolic function and regulation of this protein in SubtiPathways: Ala, Gly, Ser
MW, pI	77 kDa, 7.093
Gene length, protein length	2046 bp, 682 aa
Immediate neighbours	sdaAA, fapR
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU15870

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

Categories containing this gene/protein

DNA repair/ recombination

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: helicase C-terminal domain (according to Swiss-Prot)

• Paralogous protein(s): Mfd

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization:

Database entries

• Structure: 1GM5 (from Thermotoga maritima, 43% identity, 62% similarity)

• UniProt: O34942

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

François Lecointe, Céline Sérèna, Marion Velten, Audrey Costes, Stephen McGovern, Jean-Christophe Meile, Jeffrey Errington, S Dusko Ehrlich, Philippe Noirot, Patrice Polard
Anticipating chromosomal replication fork arrest: SSB targets repair DNA helicases to active forks.
EMBO J: 2007, 26(19);4239-51
[PubMed:17853894] [WorldCat.org] [DOI] (P p)

Humberto Sanchez, Begoña Carrasco, M Castillo Cozar, Juan C Alonso
Bacillus subtilis RecG branch migration translocase is required for DNA repair and chromosomal segregation.
Mol Microbiol: 2007, 65(4);920-35
[PubMed:17640277] [WorldCat.org] [DOI] (P p)

Qin Wen, Akeel A Mahdi, Geoffrey S Briggs, Gary J Sharples, Robert G Lloyd
Conservation of RecG activity from pathogens to hyperthermophiles.
DNA Repair (Amst): 2005, 4(1);23-31
[PubMed:15533834] [WorldCat.org] [DOI] (P p)