FolE

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  • Description: GTP cyclohydrolase I

Gene name folE
Synonyms mtrA
Essential no
Product GTP cyclohydrolase IA
Function biosynthesis of folate
Metabolic function and regulation of this protein in SubtiPathways:
Phe, Tyr, Trp, Folate
MW, pI 21 kDa, 6.335
Gene length, protein length 570 bp, 190 aa
Immediate neighbours mtrB, hbs
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
MtrA context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU22780

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

Categories containing this gene/protein

biosynthesis of cofactors

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)
  • Protein family: citrate synthase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): zinc-dependent enzyme PubMed
  • Effectors of protein activity:
  • Interactions:
  • Localization:

Database entries

  • Structure: 3D2O (enzyme from Neisseria gonorrhoeae) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation: constitutive PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References