KinD

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Gene name kinD
Synonyms ykvD
Essential no
Product two-component sensor kinase
Function initiation of sporulation
Function and regulation of this protein in SubtiPathways:
Phosphorelay
MW, pI 56 kDa, 6.745
Gene length, protein length 1518 bp, 506 aa
Immediate neighbours eag, mhqR
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
KinD context.gif
This image was kindly provided by SubtiList







The gene

Basic information

  • Locus tag: BSU13660

Phenotypes of a mutant

deletion of kinD suppresses the sporulation defect of matrix mutants, while its overproduction delays sporulation PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • autophosphorylation, phosphorylation of Spo0F, regulates the onset of sporulation by inhibiting the activity of Spo0A until matrix, or a component therein, is sensed PubMed
    • dual role as a phosphatase or a kinase, activity is linked to the presence of extracellular matrix in the biofilms PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains: two transmembrane segments, C-terminal histidine phosphotransferase domain
  • Modification: autophosphorylation on a His residue
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References