Rtp

• Description: replication terminator protein
  
  

Gene name	rtp
Synonyms
Essential	no
Product	replication terminator protein
Function	replication termination
MW, pI	14 kDa, 9.778
Gene length, protein length	366 bp, 122 aa
Immediate neighbours	proH, yoxD
Get the DNA and protein sequences (Barbe et al., 2009)
Genetic context This image was kindly provided by SubtiList

The gene

Basic information

• Locus tag: BSU18490

Database entries

• DBTBS entry: no entry

• SubtiList entry: [1]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity:

• Protein family: pyrroline-5-carboxylate reductase family (according to Swiss-Prot)

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification:

• Cofactor(s):

• Effectors of protein activity:

• Interactions:

• Localization: cytoplasm (according to Swiss-Prot)

Database entries

• Structure: 1F4K (complex with DNA), 1BM9

• UniProt: P68732

• KEGG entry: [2]

• E.C. number:

Expression and regulation

• Operon:

• Sigma factor:

• Regulation:

• Regulatory mechanism:

• Additional information:

Biological materials

• Mutant:

• Expression vector:

• lacZ fusion:

• GFP fusion:

• two-hybrid system:

• Antibody:

References

Qiaojuan Shi, Jose C Huguet-Tapia, Joseph E Peters
Tn917 targets the region where DNA replication terminates in Bacillus subtilis, highlighting a difference in chromosome processing in the firmicutes.
J Bacteriol: 2009, 191(24);7623-7
[PubMed:19820088] [WorldCat.org] [DOI] (I p)

S Autret, A Levine, F Vannier, Y Fujita, S J Séror
The replication checkpoint control in Bacillus subtilis: identification of a novel RTP-binding sequence essential for the replication fork arrest after induction of the stringent response.
Mol Microbiol: 1999, 31(6);1665-79
[PubMed:10209741] [WorldCat.org] [DOI] (P p)

A Levine, S Autret, S J Séror
A checkpoint involving RTP, the replication terminator protein, arrests replication downstream of the origin during the Stringent Response in Bacillus subtilis.
Mol Microbiol: 1995, 15(2);287-95
[PubMed:7746150] [WorldCat.org] [DOI] (P p)

D B Langley, M T Smith, P J Lewis, R G Wake
Protein-nucleoside contacts in the interaction between the replication terminator protein of Bacillus subtilis and the DNA terminator.
Mol Microbiol: 1993, 10(4);771-9
[PubMed:7934839] [WorldCat.org] [DOI] (P p)

P J Lewis, R G Wake
Termination of chromosome replication in Bacillus subtilis.
Res Microbiol: 1991, 142(7-8);893-900
[PubMed:1784827] [WorldCat.org] [DOI] (P p)

P J Lewis, G B Ralston, R I Christopherson, R G Wake
Identification of the replication terminator protein binding sites in the terminus region of the Bacillus subtilis chromosome and stoichiometry of the binding.
J Mol Biol: 1990, 214(1);73-84
[PubMed:2115089] [WorldCat.org] [DOI] (P p)

P J Lewis, M T Smith, R G Wake
A protein involved in termination of chromosome replication in Bacillus subtilis binds specifically to the terC site.
J Bacteriol: 1989, 171(6);3564-7
[PubMed:2498294] [WorldCat.org] [DOI] (P p)