NrnA

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  • Description: oligoribonuclease (nanoRNAse), 3',5'-bisphosphate nucleotidase

Gene name nrnA
Synonyms ytqI
Essential no
Product oligoribonuclease (nanoRNAse), 3',5'-bisphosphate nucleotidase
Function degradation of RNA oligonucleotides,
MW, pI 34 kDa, 4.668
Gene length, protein length 939 bp, 313 aa
Immediate neighbours ytrI, ytpI
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YtqI context.gif
This image was kindly provided by SubtiList



The gene

Basic information

  • Locus tag: BSU29250

Phenotypes of a mutant

The mutant requires cysteine PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate (according to Swiss-Prot) oligoribonuclease (nanoRNAse), 3',5'-bisphosphate nucleotidase PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Interactions:
  • Localization: Cytoplasm (Homogeneous) PubMed

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Jiaqin Zhang, Indranil Biswas
3'-Phosphoadenosine-5'-phosphate phosphatase activity is required for superoxide stress tolerance in Streptococcus mutans.
J Bacteriol: 2009, 191(13);4330-40
[PubMed:19429620] [WorldCat.org] [DOI] (I p)

Undine Mechold, Gang Fang, Saravuth Ngo, Vasily Ogryzko, Antoine Danchin
YtqI from Bacillus subtilis has both oligoribonuclease and pAp-phosphatase activity.
Nucleic Acids Res: 2007, 35(13);4552-61
[PubMed:17586819] [WorldCat.org] [DOI] (I p)

Jean-Christophe Meile, Ling Juan Wu, S Dusko Ehrlich, Jeff Errington, Philippe Noirot
Systematic localisation of proteins fused to the green fluorescent protein in Bacillus subtilis: identification of new proteins at the DNA replication factory.
Proteomics: 2006, 6(7);2135-46
[PubMed:16479537] [WorldCat.org] [DOI] (P p)