Tpi

• Description: catalyzes the transformation of glycerinaldehyd 3-phosphate to dihydroxyactonphosphate and the reverse reaktion
  
  

Gene name	tpi
Synonyms	tpiA
Essential	yes
Product	Triosephosphate isomerase
Function	isomerase
MW, pI	26,9 kDa, 4.79
Gene length, protein length	759 bp, 253 amino acids
Immediate neighbours	pgk, pgm
Gene sequence (+200bp)	Protein sequence
Genetic context File:GenE context.gif

The gene

Basic information

• Coordinates:

Database entries

• DBTBS entry: [1]

• SubtiList entry: [2]

The protein

Basic information/ Evolution

• Catalyzed reaction/ biological activity: D-glyceraldehyde 3-phosphate = glycerone phosphate

• Protein family: triosephosphate isomerase family

• Paralogous protein(s):

Extended information on the protein

• Kinetic information:

• Domains:

• Modification: phosphorylation PubMed

• Cofactor(s):

• Effectors of protein activity:

• Interactions: Pgm-TpiA

• Localization: Cytoplasm PubMed

Database entries

• Structure: complex with 2-phosphpoglycolic acid, Geobacillus stearothermophilus NCBI

• Swiss prot entry: [3]

• KEGG entry: [4]

• E.C. number: [5]

Expression and regulation

• Operon: cggR gapA pgk tpiA pgm eno

• Sigma factor: SigA

• Regulation: neg. regulated by CggR, induced by sugar

• Regulatory mechanism: repressor CggR

• Additional information:

References

1. Author1, Author2 & Author3 (year) Title Journal volume: page-page. PubMed