GabR

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Gene name gabR
Synonyms ycnF
Essential no
Product transcription regulator
Function regulation of gamma-amino butyric acid utilization
Gene expression levels in SubtiExpress: gabR
MW, pI 54 kDa, 6.709
Gene length, protein length 1437 bp, 479 aa
Immediate neighbours yczG, gabT
Sequences Protein DNA DNA_with_flanks
Genetic context
GabR context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
GabR expression.png















Categories containing this gene/protein

utilization of amino acids, transcription factors and their control

This gene is a member of the following regulons

GabR regulon

The GabR regulon:

The gene

Basic information

  • Locus tag: BSU03890

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • transcription activation of the gabT-gabD operon in the presence of GABA and PLP, transcription repression of gabR PubMed
  • Paralogous protein(s): none, but there are 7 members of the MocR/ GabR family in B. subtilis

Extended information on the protein

  • Kinetic information:
  • Domains:
    • N-terminal DNA-binding helix-turn-helix motif (corresponding to domains of the GntR family) PubMed
    • C-terminal domain is homologous to PLP-binding large domain of aminotransferases PubMed
  • Modification:
  • Effectors of protein activity:
    • activation of gabT-gabD expression is triggered by gamma-amino butyrate and pyridoxalphosphate PubMed

Database entries

  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
    • GabR: negative autoregulation PubMed
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Linc Sonenshein, Tufts University, Boston, MA, USA Homepage

Your additional remarks

References