PrsA

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  • Description: lipoprotein, post-translocational folding of exported proteins (post-translocation molecular chaperone)

Gene name prsA
Synonyms
Essential yes PubMed
Product post-translocation molecular chaperone
Function protein folding
Gene expression levels in SubtiExpress: prsA
Interactions involving this protein in SubtInteract: PrsA
Metabolic function and regulation of this protein in SubtiPathways:
Protein secretion
MW, pI 32 kDa, 9.122
Gene length, protein length 876 bp, 292 aa
Immediate neighbours yhaL, sscA
Sequences Protein DNA DNA_with_flanks
Genetic context
PrsA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
PrsA expression.png















Categories containing this gene/protein

protein secretion, essential genes, membrane proteins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU09950

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Protein family: PpiC domain (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
    • PrsA is a lipoprotein with a N-acetyl-S-diacyl-glyceryl-cysteine structure PubMed
  • Effectors of protein activity:
  • Localization:
    • membrane associated (lipoprotein) PubMed
    • distinct spots organized in a helical pattern along the cell membrane PubMed

Database entries

  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • PrsA is subject to degradation by WprA and other extracellular proteases PubMed

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References