MutS

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  • Description: DNA mismatch repair (mismatch recognition protein)

Gene name mutS
Synonyms
Essential no
Product mismatch recognition protein
Function DNA repair
Gene expression levels in SubtiExpress: mutS
Interactions involving this protein in SubtInteract: MutS
MW, pI 97 kDa, 5.189
Gene length, protein length 2574 bp, 858 aa
Immediate neighbours cotE, mutL
Sequences Protein DNA DNA_with_flanks
Genetic context
MutS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MutS expression.png















Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU17040

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • MutS recognizes mismatches in the DNA and recruits MutL to the site of mismatch recognition
  • Protein family: DNA mismatch repair mutS family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • forms foci at midcell position, the frequency of foci increases upon mismatch formation PubMed
    • replication-active region of the DNA, via DnaN PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Original publications