ProH

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  • Description: pyrroline-5-carboxylate reductase

Gene name proH
Synonyms yoxE
Essential no
Product pyrroline-5-carboxylate reductase
Function osmoadaptive de novo production of proline
Gene expression levels in SubtiExpress: proH
Metabolic function and regulation of this protein in SubtiPathways:
Pro, Stress
MW, pI 31 kDa, 7.754
Gene length, protein length 891 bp, 297 aa
Immediate neighbours proJ, rtp
Sequences Protein DNA Advanced_DNA
Genetic context
ProH context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
ProH expression.png




























Categories containing this gene/protein

biosynthesis/ acquisition of amino acids, coping with hyper-osmotic stress

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU18480

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H (according to Swiss-Prot)
  • Protein family: glutamate 5-kinase family (according to Swiss-Prot)
  • Paralogous protein(s): ProI

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Regulation:
    • expressed under conditions of osmotic stress PubMed
    • induced by cold stress PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed