ProG

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  • Description: 1-pyrroline-5-carboxylate dehydrogenase, the precise role of ProG is unknown

Gene name proG
Synonyms ykeA, yzcA
Essential no
Product 1-pyrroline-5-carboxylate dehydrogenase
Function biosynthesis of proline
Metabolic function and regulation of this protein in SubtiPathways:
Pro, Stress
MW, pI 30 kDa, 4.914
Gene length, protein length 816 bp, 272 aa
Immediate neighbours htrA, dppA
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
ProG context.gif
This image was kindly provided by SubtiList







Categories containing this gene/protein

biosynthesis/ acquisition of amino acids

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU12910

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: L-proline + NAD(P)+ = 1-pyrroline-5-carboxylate + NAD(P)H (according to Swiss-Prot)
  • Protein family: pyrroline-5-carboxylate reductase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

B R Belitsky, J Brill, E Bremer, A L Sonenshein
Multiple genes for the last step of proline biosynthesis in Bacillus subtilis.
J Bacteriol: 2001, 183(14);4389-92
[PubMed:11418582] [WorldCat.org] [DOI] (P p)

C Mathiopoulos, J P Mueller, F J Slack, C G Murphy, S Patankar, G Bukusoglu, A L Sonenshein
A Bacillus subtilis dipeptide transport system expressed early during sporulation.
Mol Microbiol: 1991, 5(8);1903-13
[PubMed:1766370] [WorldCat.org] [DOI] (P p)