Difference between revisions of "NrdI"
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=The gene= | =The gene= |
Revision as of 07:46, 23 June 2009
- Description: ribonucleoside-diphosphate reductase
Gene name | nrdI |
Synonyms | ymaA |
Essential | yes PubMed |
Product | ribonucleoside-diphosphate reductase |
Function | synthesis of deoxyribonucleoside triphosphates |
Metabolic function and regulation of this protein in SubtiPathways: Nucleotides (regulation) | |
MW, pI | 14 kDa, 8.58 |
Gene length, protein length | 390 bp, 130 aa |
Immediate neighbours | ymzA, nrdE |
Gene sequence (+200bp) | Protein sequence |
Genetic context ![]() This image was kindly provided by SubtiList
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Contents
The gene
Basic information
- Locus tag: BSU17370
Phenotypes of a mutant
essential PubMed
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family: nrdI family (according to Swiss-Prot)
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Interactions:
- Localization:
Database entries
- Structure: 1RLJ
- Swiss prot entry: P50618
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Regulation: distinct promoters for aerobic and anaerobic expression PubMed, anaerobic expression requires ResD PubMed
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Elisabeth Härtig, Anja Hartmann, Manuela Schätzle, Alessandra M Albertini, Dieter Jahn
The Bacillus subtilis nrdEF genes, encoding a class Ib ribonucleotide reductase, are essential for aerobic and anaerobic growth.
Appl Environ Microbiol: 2006, 72(8);5260-5
[PubMed:16885274]
[WorldCat.org]
[DOI]
(P p)
C Scotti, A Valbuzzi, M Perego, A Galizzi, A M Albertini
The Bacillus subtilis genes for ribonucleotide reductase are similar to the genes for the second class I NrdE/NrdF enzymes of Enterobacteriaceae.
Microbiology (Reading): 1996, 142 ( Pt 11);2995-3004
[PubMed:8969495]
[WorldCat.org]
[DOI]
(P p)