Difference between revisions of "ComS"
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<pubmed>17560370,10447896,,9000055, 10361283, 10447896, 11703662 </pubmed> | <pubmed>17560370,10447896,,9000055, 10361283, 10447896, 11703662 </pubmed> | ||
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Revision as of 13:05, 15 June 2009
- Description: antiadaptor protein, assembly link between regulatory components of the competence signal transduction pathway
Gene name | comS |
Synonyms | |
Essential | no |
Product | antiadaptor protein (anti-MecA) |
Function | control of ComK degradation |
MW, pI | 5 kDa, 9.145 |
Gene length, protein length | 138 bp, 46 aa |
Immediate neighbours | srfAB, srfAC |
Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context This image was kindly provided by SubtiList
|
Contents
The gene
Basic information
- Locus tag: BSU03500
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
- Localization:
Database entries
- Structure:
- Swiss prot entry: P80355
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon:
- Regulation:
- Regulatory mechanism:
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Peter Prepiak, David Dubnau
A peptide signal for adapter protein-mediated degradation by the AAA+ protease ClpCP.
Mol Cell: 2007, 26(5);639-47
[PubMed:17560370]
[WorldCat.org]
[DOI]
(P p)
M M Nakano, F Hajarizadeh, Y Zhu, P Zuber
Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilis.
Mol Microbiol: 2001, 42(2);383-94
[PubMed:11703662]
[WorldCat.org]
[DOI]
(P p)
M Persuh, K Turgay, I Mandic-Mulec, D Dubnau
The N- and C-terminal domains of MecA recognize different partners in the competence molecular switch.
Mol Microbiol: 1999, 33(4);886-94
[PubMed:10447896]
[WorldCat.org]
[DOI]
(P p)
M Ogura, L Liu, M Lacelle, M M Nakano, P Zuber
Mutational analysis of ComS: evidence for the interaction of ComS and MecA in the regulation of competence development in Bacillus subtilis.
Mol Microbiol: 1999, 32(4);799-812
[PubMed:10361283]
[WorldCat.org]
[DOI]
(P p)
K Turgay, L W Hamoen, G Venema, D Dubnau
Biochemical characterization of a molecular switch involving the heat shock protein ClpC, which controls the activity of ComK, the competence transcription factor of Bacillus subtilis.
Genes Dev: 1997, 11(1);119-28
[PubMed:9000055]
[WorldCat.org]
[DOI]
(P p)