Difference between revisions of "Fra"

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* '''Additional information:'''
 
* '''Additional information:'''
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** number of protein molecules per cell (minimal medium with glucose and ammonium): 178 {{PubMed|24696501}}
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** number of protein molecules per cell (complex medium with amino acids, without glucose): 451 {{PubMed|24696501}}
  
 
=Biological materials =
 
=Biological materials =

Revision as of 11:25, 17 April 2014

  • Description: frataxin-like protein, required for the biosynthesis of iron-sulfur clusters

Gene name fra
Synonyms ydhG
Essential no
Product frataxin-like protein
Function intracellular iron channeling, biosynthesis of iron-sulfur clusters
Gene expression levels in SubtiExpress: fra
Interactions involving this protein in SubtInteract: Fra
Metabolic function and regulation of this protein in SubtiPathways:
Fra
MW, pI 14 kDa, 5.377
Gene length, protein length 369 bp, 123 aa
Immediate neighbours phoB, ydhH
Sequences Protein DNA DNA_with_flanks
Genetic context
YdhG context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
Fra expression.png
























Categories containing this gene/protein

iron metabolism

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU05750

Phenotypes of a mutant

  • severe growth phenotype associated with a broadly disturbed iron homeostasis PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: transfers iron onto the B. subtilis SUF system (SufU-SufS) for iron-sulfur cluster biosynthesis PubMed
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): Fe(2+) is bound with high affinity PubMed
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Operon:
  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:
    • number of protein molecules per cell (minimal medium with glucose and ammonium): 178 PubMed
    • number of protein molecules per cell (complex medium with amino acids, without glucose): 451 PubMed

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Additional publications: PubMed

Wenbin Qi, J A Cowan
A structural and functional homolog supports a general role for frataxin in cellular iron chemistry.
Chem Commun (Camb): 2010, 46(5);719-21
[PubMed:20087498] [WorldCat.org] [DOI] (I p)