Difference between revisions of "TrxB"

From SubtiWiki
Jump to: navigation, search
(Categories containing this gene/protein)
Line 77: Line 77:
 
* '''Kinetic information:'''
 
* '''Kinetic information:'''
  
* '''Domains:'''  
+
* '''[[Domains]]:'''  
  
 
* '''Modification:'''
 
* '''Modification:'''
  
* '''Cofactor(s):'''
+
* '''[[Cofactors]]:'''
  
 
* '''Effectors of protein activity:'''
 
* '''Effectors of protein activity:'''
Line 140: Line 140:
 
<pubmed> 23899494 </pubmed>
 
<pubmed> 23899494 </pubmed>
 
== Original publications ==
 
== Original publications ==
<pubmed> 20084284 12642660 20525796</pubmed>
+
<pubmed> 20084284 12642660 20525796 24401092 </pubmed>
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 09:51, 10 January 2014

  • Description: thioredoxin reductase (NADPH)

Gene name trxB
Synonyms yvcH
Essential yes PubMed
Product thioredoxin reductase (NADPH)
Function keeps thioredoxin in the reduced state
Gene expression levels in SubtiExpress: trxB
MW, pI 34 kDa, 4.99
Gene length, protein length 948 bp, 316 aa
Immediate neighbours yvcI, cwlO
Sequences Protein DNA DNA_with_flanks
Genetic context
TrxB context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
TrxB expression.png















Categories containing this gene/protein

electron transport/ other, resistance against oxidative and electrophile stress, essential genes

This gene is a member of the following regulons

Spx regulon

The gene

Basic information

  • Locus tag: BSU34790

Phenotypes of a mutant

essential PubMed

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: Thioredoxin + NADP+ = thioredoxin disulfide + NADPH (according to Swiss-Prot)
  • Protein family: class-II pyridine nucleotide-disulfide oxidoreductase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Modification:
  • Effectors of protein activity:

Database entries

  • Structure:
  • KEGG entry: [2]

Additional information

Expression and regulation

  • Operon:
  • Regulation:
  • Regulatory mechanism:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Jun Lu, Arne Holmgren
The thioredoxin antioxidant system.
Free Radic Biol Med: 2014, 66;75-87
[PubMed:23899494] [WorldCat.org] [DOI] (I p)

Original publications