Difference between revisions of "FolE"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU22780 folE]
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU22780 folE]
 
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/phenyl_tyr_tryp.html Phe, Tyr, Trp], [http://subtiwiki.uni-goettingen.de/pathways/folate_biosynthesis.html Folate]'''
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/subtipathways/search.php?enzyme=folE folE]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 21 kDa, 6.335   
 
|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 21 kDa, 6.335   

Revision as of 11:05, 7 January 2014

  • Description: GTP cyclohydrolase I

Gene name folE
Synonyms mtrA
Essential no
Product GTP cyclohydrolase IA
Function biosynthesis of folate
Gene expression levels in SubtiExpress: folE
Metabolic function and regulation of this protein in SubtiPathways:
folE
MW, pI 21 kDa, 6.335
Gene length, protein length 570 bp, 190 aa
Immediate neighbours mtrB, hbs
Sequences Protein DNA DNA_with_flanks
Genetic context
MtrA context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
FolE expression.png




























Categories containing this gene/protein

biosynthesis of cofactors

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU22780

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate (according to Swiss-Prot)
  • Protein family: citrate synthase family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s): zinc-dependent enzyme PubMed
  • Effectors of protein activity:

Database entries

  • Structure: 3D2O (enzyme from Neisseria gonorrhoeae) PubMed
  • KEGG entry: [3]

Additional information

Expression and regulation

  • Regulation: constitutive PubMed
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References