Difference between revisions of "NdoAI"

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* '''Description:''' antitoxin, antagonist for [[NdoA|EndoA]] <br/><br/>
 
 
 
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* '''[[SubtInteract|Interactions]]:'''
 
* '''[[SubtInteract|Interactions]]:'''
** [[NdoAI]]-[[NdoA|EndoA]] {{PubMed|17416361}}
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** [[NdoA]](2)-[[NdoAI]](2)-[[NdoA]](2) {{PubMed|24120662,17416361}}
  
 
* '''[[Localization]]:'''
 
* '''[[Localization]]:'''
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* '''Structure:'''
 
* '''Structure:'''
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** [http://www.rcsb.org/pdb/explore.do?structureId=4ME7 4ME7] ([[NdoA]]-[[NdoAI]] complex) {{PubMed|24120662}}
  
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P96621 P96621]
 
* '''UniProt:''' [http://www.uniprot.org/uniprot/P96621 P96621]
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=References=
 
=References=
  
<pubmed>17416361,15882409,, </pubmed>
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<pubmed>17416361,15882409,24120662, </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 09:23, 21 October 2013

  • Description: antitoxin, antagonist for EndoA

Gene name ndoAI
Synonyms ydcD
Essential no
Product antitoxin
Function inhibition of NdoA
Gene expression levels in SubtiExpress: ndoAI
Interactions involving this protein in SubtInteract: NdoAI
MW, pI 10 kDa, 6.138
Gene length, protein length 279 bp, 93 aa
Immediate neighbours alr, ndoA
Sequences Protein DNA DNA_with_flanks
Genetic context
YdcD context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
NdoAI expression.png















Categories containing this gene/protein

toxins, antitoxins and immunity against toxins

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU04650

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry: [1]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family: mazE/ndoAI family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:

Database entries

  • KEGG entry: [2]
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Dhirendra K Simanshu, Yoshihiro Yamaguchi, Jung-Ho Park, Masayori Inouye, Dinshaw J Patel
Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis.
Mol Cell: 2013, 52(3);447-58
[PubMed:24120662] [WorldCat.org] [DOI] (I p)

Shivangi Agarwal, Shivani Agarwal, Rakesh Bhatnagar
Identification and characterization of a novel toxin-antitoxin module from Bacillus anthracis.
FEBS Lett: 2007, 581(9);1727-34
[PubMed:17416361] [WorldCat.org] [DOI] (P p)

Olivier Pellegrini, Nathalie Mathy, Arhonda Gogos, Lawrence Shapiro, Ciarán Condon
The Bacillus subtilis ydcDE operon encodes an endoribonuclease of the MazF/PemK family and its inhibitor.
Mol Microbiol: 2005, 56(5);1139-48
[PubMed:15882409] [WorldCat.org] [DOI] (P p)