Difference between revisions of "MutS"

From SubtiWiki
Jump to: navigation, search
Line 146: Line 146:
  
 
=References=
 
=References=
 +
==Reviews==
 +
<pubmed> 22933559 </pubmed>
 +
== Original publications ==
 
<pubmed>8760914, 15375129,16479537 20525796 20453097 23228104 21958350 23882084 23998896 </pubmed>
 
<pubmed>8760914, 15375129,16479537 20525796 20453097 23228104 21958350 23882084 23998896 </pubmed>
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 17:24, 13 September 2013

  • Description: DNA mismatch repair (mismatch recognition protein)

Gene name mutS
Synonyms
Essential no
Product mismatch recognition protein
Function DNA repair
Gene expression levels in SubtiExpress: mutS
Interactions involving this protein in SubtInteract: MutS
MW, pI 97 kDa, 5.189
Gene length, protein length 2574 bp, 858 aa
Immediate neighbours cotE, mutL
Sequences Protein DNA DNA_with_flanks
Genetic context
MutS context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
MutS expression.png















Categories containing this gene/protein

DNA repair/ recombination

This gene is a member of the following regulons

The gene

Basic information

  • Locus tag: BSU17040

Phenotypes of a mutant

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
    • MutS recognizes mismatches in the DNA and recruits MutL to the site of mismatch recognition
  • Protein family: DNA mismatch repair mutS family (according to Swiss-Prot)
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity:
  • Localization:
    • forms foci at midcell position, the frequency of foci increases upon mismatch formation PubMed
    • replication-active region of the DNA, via DnaN PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Regulation:
  • Regulatory mechanism:

Biological materials

  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Justin S Lenhart, Jeremy W Schroeder, Brian W Walsh, Lyle A Simmons
DNA repair and genome maintenance in Bacillus subtilis.
Microbiol Mol Biol Rev: 2012, 76(3);530-64
[PubMed:22933559] [WorldCat.org] [DOI] (I p)

Original publications