Difference between revisions of "TapA"

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= [[Categories]] containing this gene/protein =
 
= [[Categories]] containing this gene/protein =
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= This gene is a member of the following [[regulons]] =
 
= This gene is a member of the following [[regulons]] =
 
{{SubtiWiki regulon|[[AbrB regulon]]}},
 
{{SubtiWiki regulon|[[AbrB regulon]]}},
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{{SubtiWiki regulon|[[RemA regulon]]}},
 
{{SubtiWiki regulon|[[SinR regulon]]}}
 
{{SubtiWiki regulon|[[SinR regulon]]}}
  
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* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqxM_2554486_2555247_-1 tapA] {{PubMed|22383849}}
 
* '''Expression browser:''' [http://genome.jouy.inra.fr/cgi-bin/seb/viewdetail.py?id=yqxM_2554486_2555247_-1 tapA] {{PubMed|22383849}}
  
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* '''Sigma factor:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16430695 PubMed]
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* '''[[Sigma factor]]:''' [[SigA]] [http://www.ncbi.nlm.nih.gov/sites/entrez/16430695 PubMed]
  
 
* '''Regulation:'''  
 
* '''Regulation:'''  
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** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed]
 
** [[AbrB]]:  transcription repression [http://www.ncbi.nlm.nih.gov/sites/entrez/10464223,17720793 PubMed]
 
** [[SinR]]: transcription repression {{PubMed|16430695}}
 
** [[SinR]]: transcription repression {{PubMed|16430695}}
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** [[RemA]]: transcription activation {{PubMed|23646920}}
  
 
* '''Additional information:'''  
 
* '''Additional information:'''  
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<pubmed> 21488983 </pubmed>
 
<pubmed> 21488983 </pubmed>
 
==Original publications==
 
==Original publications==
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<big>''Diethmaier C, Pietack N, Gunka K, Wrede C, Lehnik-Habrink M, Herzberg C, Hübner S, Stülke J''  </big>
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<pubmed>18430133,18047568,18647168, 20351052,16430695,10464223,17720793, 19605685 20431016 10559173 21477127 21856853 21815947 23646920</pubmed>
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<big>'''A Novel Factor Controlling Bistability in ''Bacillus subtilis'': The YmdB Protein Affects</big>
 
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<big>Flagellin Expression and Biofilm Formation.''' </big>
 
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<big>J Bacteriol.: 2011, 193(21):5997-6007. </big>
 
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[http://www.ncbi.nlm.nih.gov/pubmed/21856853 PubMed:21856853]
 
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<big>''Lehnik-Habrink M, Schaffer M, Mäder U, Diethmaier C, Herzberg C, Stülke J''  </big>
 
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<big>'''RNA processing in ''Bacillus subtilis'': identification of targets of the essential RNase Y.''' </big>
 
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<big>Mol Microbiol. 2011 81(6): 1459-1473. </big>
 
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[http://www.ncbi.nlm.nih.gov/pubmed/21815947 PubMed:21815947]
 
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<pubmed>18430133,18047568,18647168, 20351052,16430695,10464223,17720793, 19605685 20431016 10559173 21477127 </pubmed>
 
  
 
[[Category:Protein-coding genes]]
 
[[Category:Protein-coding genes]]

Revision as of 15:19, 24 May 2013

  • Description: required for the anchoring of the TasA amyloid fibers to the cell and for the initiation of fiber polymerization, minor fiber component



Gene name tapA
Synonyms yqhD, yqxM
Essential no
Product TasA anchoring/assembly protein
Function biofilm formation
Gene expression levels in SubtiExpress: tapA
Interactions involving this protein in SubtInteract: TapA
Regulation of this protein in SubtiPathways:
Biofilm, Protein secretion
MW, pI 28 kDa, 6.677
Gene length, protein length 759 bp, 253 aa
Immediate neighbours sipW, yqzG
Sequences Protein DNA DNA_with_flanks
Genetic context
YqxM context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
TapA expression.png















Categories containing this gene/protein

biofilm formation, membrane proteins

This gene is a member of the following regulons

AbrB regulon, RemA regulon, SinR regulon

The gene

Basic information

  • Locus tag: BSU24640

Phenotypes of a mutant

The mutants are able to form a biofilm in the presence of D-amino acids PubMed

Database entries

  • DBTBS entry: [1]
  • SubtiList entry: [2]

Additional information

The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity:
  • Protein family:
  • Paralogous protein(s):

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: D-amino acids lead to disappearance of TapA from the cell wall PubMed
  • Localization:
    • attached to the cell surface (on the outside of the cell), associated with peptidoglycan PubMed
    • secretion requires SipW PubMed

Database entries

  • Structure:
  • KEGG entry: [3]
  • E.C. number:

Additional information

Expression and regulation

  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion: pGP1926 (in pAC6), available in Stülke lab
  • GFP fusion:
  • two-hybrid system:
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Reviews

Adam Driks
Tapping into the biofilm: insights into assembly and disassembly of a novel amyloid fibre in Bacillus subtilis.
Mol Microbiol: 2011, 80(5);1133-6
[PubMed:21488983] [WorldCat.org] [DOI] (I p)

Original publications

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