Difference between revisions of "HemD"
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|style="background:#ABCDEF;" align="center"|'''Function''' || heme biosynthesis | |style="background:#ABCDEF;" align="center"|'''Function''' || heme biosynthesis | ||
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| − | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http:// | + | |colspan="2" style="background:#FAF8CC;" align="center"| '''Gene expression levels in [http://subtiwiki.uni-goettingen.de/apps/expression/ ''Subti''Express]''': [http://subtiwiki.uni-goettingen.de/apps/expression/expression.php?search=BSU28140 hemD] |
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 5.087 | |style="background:#ABCDEF;" align="center"| '''MW, pI''' || 28 kDa, 5.087 | ||
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|style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hemB]]'', ''[[hemC]]'' | |style="background:#ABCDEF;" align="center"|'''Immediate neighbours''' || ''[[hemB]]'', ''[[hemC]]'' | ||
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| − | | | + | |style="background:#FAF8CC;" align="center"|'''Sequences'''||[http://bsubcyc.org/BSUB/sequence-aa?type=GENE&object=BSU28140 Protein] [http://bsubcyc.org/BSUB/sequence?type=GENE&object=BSU28140 DNA] [http://bsubcyc.org/BSUB/seq-selector?chromosome=CHROM-1&object=BSU28140 Advanced_DNA] |
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|colspan="2" | '''Genetic context''' <br/> [[Image:hemD_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:hemD_context.gif]] | ||
Revision as of 13:29, 13 May 2013
- Description: uroporphyrinogen-III synthase
| Gene name | hemD |
| Synonyms | |
| Essential | no |
| Product | uroporphyrinogen-III synthase |
| Function | heme biosynthesis |
| Gene expression levels in SubtiExpress: hemD | |
| MW, pI | 28 kDa, 5.087 |
| Gene length, protein length | 786 bp, 262 aa |
| Immediate neighbours | hemB, hemC |
| Sequences | Protein DNA Advanced_DNA |
Genetic context 
This image was kindly provided by SubtiList
| |
Expression at a glance PubMed
| |
Contents
Categories containing this gene/protein
This gene is a member of the following regulons
The gene
Basic information
- Locus tag: BSU28140
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity: Hydroxymethylbilane = uroporphyrinogen III + H2O (according to Swiss-Prot)
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s):
- Effectors of protein activity:
Database entries
- Structure:
- UniProt: P21248
- KEGG entry: [3]
- E.C. number: 4.2.1.75
Additional information
Expression and regulation
- Additional information:
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Germán Plata, Tobias Fuhrer, Tzu-Lin Hsiao, Uwe Sauer, Dennis Vitkup
Global probabilistic annotation of metabolic networks enables enzyme discovery.
Nat Chem Biol: 2012, 8(10);848-54
[PubMed:22960854]
[WorldCat.org]
[DOI]
(I p)
A F Herbig, J D Helmann
Roles of metal ions and hydrogen peroxide in modulating the interaction of the Bacillus subtilis PerR peroxide regulon repressor with operator DNA.
Mol Microbiol: 2001, 41(4);849-59
[PubMed:11532148]
[WorldCat.org]
[DOI]
(P p)
Per Johansson, Lars Hederstedt
Organization of genes for tetrapyrrole biosynthesis in gram--positive bacteria.
Microbiology (Reading): 1999, 145 ( Pt 3);529-538
[PubMed:10217486]
[WorldCat.org]
[DOI]
(P p)
N P Stamford, A Capretta, A R Battersby
Expression, purification and characterisation of the product from the Bacillus subtilis hemD gene, uroporphyrinogen III synthase.
Eur J Biochem: 1995, 231(1);236-41
[PubMed:7628476]
[WorldCat.org]
[DOI]
(P p)
M Hansson, L Rutberg, I Schröder, L Hederstedt
The Bacillus subtilis hemAXCDBL gene cluster, which encodes enzymes of the biosynthetic pathway from glutamate to uroporphyrinogen III.
J Bacteriol: 1991, 173(8);2590-9
[PubMed:1672867]
[WorldCat.org]
[DOI]
(P p)
