Difference between revisions of "SlrA"

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|colspan="2" style="background:#FAF8CC;" align="center"| '''Regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm]'''
 
|colspan="2" style="background:#FAF8CC;" align="center"| '''Regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/biofilm.html Biofilm]'''
 
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 6 kDa, 9.992  
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|style="background:#ABCDEF;" align="center"| '''MW, pI''' || 6.1 kDa, 9.992  
 
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|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 156 bp, 52 aa
 
|style="background:#ABCDEF;" align="center"| '''Gene length, protein length''' || 156 bp, 52 aa

Revision as of 13:23, 22 November 2012

  • Description: anti-repressor, antagonist of SinR and SlrR, involved in control of flagellar genes and eps and tapA-sipW-tasA operons

Gene name slrA
Synonyms
Essential no
Product antagonist of SinR and SlrR
Function control of biofilm formation
Gene expression levels in SubtiExpress: slrA
Interactions involving this protein in SubtInteract: SlrA
Regulation of this protein in SubtiPathways:
Biofilm
MW, pI 6.1 kDa, 9.992
Gene length, protein length 156 bp, 52 aa
Immediate neighbours ywcC, ywcB
Get the DNA and protein sequences
(Barbe et al., 2009)
Genetic context
YwcC context.gif
This image was kindly provided by SubtiList
Expression at a glance   PubMed
SlrA expression.png




























Categories containing this gene/protein

transcription factors and their control, transition state regulators, biofilm formation

This gene is a member of the following regulons

YwcC regulon

The gene

Basic information

  • Locus tag: BSU38229

Phenotypes of a mutant

Database entries

  • DBTBS entry: no entry
  • SubtiList entry:

Additional information

This gene was only recently identified. PubMed


The protein

Basic information/ Evolution

  • Catalyzed reaction/ biological activity: binding of SinR resulting in induction of SinR-repressed genes and operons PubMed
  • Protein family:
  • Paralogous protein(s): SinI

Extended information on the protein

  • Kinetic information:
  • Domains:
  • Modification:
  • Cofactor(s):
  • Effectors of protein activity: SlrR inhibits activity of SlrA (i. e. binding to SinR) PubMed

Database entries

  • Structure:
  • KEGG entry: no entry
  • E.C. number:

Additional information

Expression and regulation

  • Sigma factor:
  • Regulation:
  • Regulatory mechanism:
  • Additional information:

Biological materials

  • Mutant:
  • Expression vector:
  • lacZ fusion:
  • GFP fusion:
  • two-hybrid system: B. pertussis adenylate cyclase-based bacterial two hybrid system (BACTH), available in Stülke lab
  • Antibody:

Labs working on this gene/protein

Your additional remarks

References

Yunrong Chai, Roberto Kolter, Richard Losick
Paralogous antirepressors acting on the master regulator for biofilm formation in Bacillus subtilis.
Mol Microbiol: 2009, 74(4);876-87
[PubMed:19788541] [WorldCat.org] [DOI] (I p)

Kazuo Kobayashi
SlrR/SlrA controls the initiation of biofilm formation in Bacillus subtilis.
Mol Microbiol: 2008, 69(6);1399-410
[PubMed:18647168] [WorldCat.org] [DOI] (I p)