Difference between revisions of "Btr"
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| − | + | * '''Description:''' transcription activator (AraC family DNA-binding domain fused to [[FeuA]]-like substrate-binding domain), regulation of the ''[[feuA]]-[[feuB]]-[[feuC]]-[[ybbA]]'' operon <br/><br/> | |
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|style="background:#ABCDEF;" align="center"|'''Function''' || regulation of iron acquisition | |style="background:#ABCDEF;" align="center"|'''Function''' || regulation of iron acquisition | ||
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|colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress], [http://cellpublisher.gobics.de/view/GqbblRJkBH Metal ion homeostasis]''' | |colspan="2" style="background:#FAF8CC;" align="center"| '''Metabolic function and regulation of this protein in [[SubtiPathways|''Subti''Pathways]]: <br/>[http://subtiwiki.uni-goettingen.de/pathways/stress_response.html Stress], [http://cellpublisher.gobics.de/view/GqbblRJkBH Metal ion homeostasis]''' | ||
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|colspan="2" | '''Genetic context''' <br/> [[Image:ybbB_context.gif]] | |colspan="2" | '''Genetic context''' <br/> [[Image:ybbB_context.gif]] | ||
<div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | <div align="right"> <small>This image was kindly provided by [http://genolist.pasteur.fr/SubtiList/ SubtiList]</small></div> | ||
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__TOC__ | __TOC__ | ||
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* '''Operon:''' ''btr'' {{PubMed|12354229}} | * '''Operon:''' ''btr'' {{PubMed|12354229}} | ||
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* '''Regulation:''' | * '''Regulation:''' | ||
Revision as of 10:35, 7 August 2012
- Description: transcription activator (AraC family DNA-binding domain fused to FeuA-like substrate-binding domain), regulation of the feuA-feuB-feuC-ybbA operon
| Gene name | btr |
| Synonyms | ybbB, yzbC |
| Essential | no |
| Product | transcription activator (AraC family) |
| Function | regulation of iron acquisition |
| Metabolic function and regulation of this protein in SubtiPathways: Stress, Metal ion homeostasis | |
| MW, pI | 60 kDa, 6.433 |
| Gene length, protein length | 1587 bp, 529 aa |
| Immediate neighbours | feuA, ybbC |
| Get the DNA and protein sequences (Barbe et al., 2009) | |
Genetic context 
This image was kindly provided by SubtiList
| |
Contents
Categories containing this gene/protein
acquisition of iron, iron metabolism, transcription factors and their control
This gene is a member of the following regulons
The Btr regulon:
The gene
Basic information
- Locus tag: BSU01640
Phenotypes of a mutant
Database entries
- DBTBS entry: [1]
- SubtiList entry: [2]
Additional information
The protein
Basic information/ Evolution
- Catalyzed reaction/ biological activity:
- Protein family:
- Paralogous protein(s):
Extended information on the protein
- Kinetic information:
- Domains:
- Modification:
- Cofactor(s): enterobactin, bacillibactin (co-activators) PubMed
- Effectors of protein activity: enterobactin, bacillibactin (co-activators) PubMed
- Interactions:
- Btr-RNA polymerase (perhaps SigA) PubMed
Database entries
- Structure:
- UniProt: P40408
- KEGG entry: [3]
- E.C. number:
Additional information
Expression and regulation
- Operon: btr PubMed
- Additional information:
- the mRNA is very stable (half-life > 15 min) PubMed
Biological materials
- Mutant:
- Expression vector:
- lacZ fusion:
- GFP fusion:
- two-hybrid system:
- Antibody:
Labs working on this gene/protein
Your additional remarks
References
Ahmed Gaballa, Shawn MacLellan, John D Helmann
Transcription activation by the siderophore sensor Btr is mediated by ligand-dependent stimulation of promoter clearance.
Nucleic Acids Res: 2012, 40(8);3585-95
[PubMed:22210890]
[WorldCat.org]
[DOI]
(I p)
Ahmed Gaballa, John D Helmann
Substrate induction of siderophore transport in Bacillus subtilis mediated by a novel one-component regulator.
Mol Microbiol: 2007, 66(1);164-73
[PubMed:17725565]
[WorldCat.org]
[DOI]
(P p)
G Hambraeus, C von Wachenfeldt, L Hederstedt
Genome-wide survey of mRNA half-lives in Bacillus subtilis identifies extremely stable mRNAs.
Mol Genet Genomics: 2003, 269(5);706-14
[PubMed:12884008]
[WorldCat.org]
[DOI]
(P p)
Noel Baichoo, Tao Wang, Rick Ye, John D Helmann
Global analysis of the Bacillus subtilis Fur regulon and the iron starvation stimulon.
Mol Microbiol: 2002, 45(6);1613-29
[PubMed:12354229]
[WorldCat.org]
[DOI]
(P p)
